Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Nov 23:13:987662.
doi: 10.3389/fmicb.2022.987662. eCollection 2022.

Alternative strategies for Chlamydia treatment: Promising non-antibiotic approaches

Chen Hou  1 , Yingqi Jin  1 , Hua Wu  2 , Pengyi Li  1 , Longyun Liu  1 , Kang Zheng  2 , Chuan Wang  1
Affiliations
Review

Alternative strategies for Chlamydia treatment: Promising non-antibiotic approaches

Chen Hou et al. Front Microbiol. .

Abstract

Chlamydia is an obligate intracellular bacterium where most species are pathogenic and infectious, causing various infectious diseases and complications in humans and animals. Antibiotics are often recommended for the clinical treatment of chlamydial infections. However, extensive research has shown that antibiotics may not be sufficient to eliminate or inhibit infection entirely and have some potential risks, including antibiotic resistance. The impact of chlamydial infection and antibiotic misuse should not be underestimated in public health. This study explores the possibility of new therapeutic techniques, including a review of recent studies on preventing and suppressing chlamydial infection by non-antibiotic compounds.

Keywords: Chlamydia; anti-chlamydial compounds; antibiotic therapy; chlamydial infection; non-antibiotic approaches.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Abraham S., Juel H. B., Bang P., Cheeseman H. M., Dohn R. B., Cole T., et al. . (2019). Safety and immunogenicity of the chlamydia vaccine candidate CTH522 adjuvanted with CAF01 liposomes or aluminium hydroxide: a first-in-human, randomised, double-blind, placebo-controlled, phase 1 trial. Lancet. Infect. Dis. 19, 1091–1100. 10.1016/S1473-3099(19)30279-8 - DOI - PubMed
    1. Adamson P. C., Klausner J. D. (2018). No benefit of chlamydia screening in primary care? Lancet. 392, 1381–1383. 10.1016/S0140-6736(18)32465-6 - DOI - PubMed
    1. Alvesalo J., Vuorela H., Tammela P., Leinonen M., Saikku P., Vuorela P., et al. . (2006). Inhibitory effect of dietary phenolic compounds on Chlamydia. pneumoniae in cell cultures. Biochem. Pharmacol. 71, 735–741. 10.1016/j.bcp.2005.12.006 - DOI - PubMed
    1. Angelucci F., Cechova K., Amlerova J., Hort J. (2019). Antibiotics, gut microbiota, and Alzheimer's disease. J. Neuroinflamm. 16, 108. 10.1186/s12974-019-1494-4 - DOI - PMC - PubMed
    1. Azenabor A. A., York J. (2010). Chlamydia trachomatis evokes a relative anti-inflammatory response in a free Ca2+ dependent manner in human macrophages. Comp. Immunol. Microbiol. Infect. Dis. 33, 513–528. 10.1016/j.cimid.2009.09.002 - DOI - PubMed

LinkOut - more resources