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Meta-Analysis
. 2022 Nov 25:10:980603.
doi: 10.3389/fpubh.2022.980603. eCollection 2022.

Shift work is significantly and positively associated with possible gastro-esophageal reflux disease: A meta-analysis study

Hsiang-Tai Chen  1 , Hung-Yi Chuang  2   3 , Tsung-Yu Hsieh  4 , Pei-Shan Wu  4 , Fang-Jiun Lin  5 , Huan-Chih Huang  6 , Chen-Cheng Yang  2   4   7 , Chao-Hung Kuo  8
Affiliations
Meta-Analysis

Shift work is significantly and positively associated with possible gastro-esophageal reflux disease: A meta-analysis study

Hsiang-Tai Chen et al. Front Public Health. .

Abstract

Background: One of the health issues related to shift work patterns is possible gastro-esophageal reflux disease (GERD) symptoms. However, the association between shift work and possible GERD symptoms through meta-analysis has not been developed in the current literature field. Therefore, the purpose of this study is to analyze the association between shift work and possible GERD symptoms through meta-analysis.

Methods: Studies containing target keywords were found in three datasets, and four articles were selected for further analysis after examining the title, abstract, and text. All prevalence odds ratios (ORs) among different groups of the population and the standard error (SE) from each included study were calculated for conducting meta-analysis.

Result: The pooled OR has shown a significant positive association between shift work and possible GERD (OR 1.53; 95% confidence interval [CI] 1.33-1.77, p-value 0.003). Compared to non-shift workers, the subgroup analysis indicates there are positive associations between possible GERD and the night shift (OR 1.39; 95% CI 1.16-1.66), and the rotating shift (OR 1.83; 95% CI 1.44-2.33). The subgroup analysis has also shown similar trends in shift working men (OR 1.28; 95% CI 1.03-1.60) and shift workers of both genders (OR 1.75; 95% CI 1.45-2.11).

Conclusion: This study has shown a positive association between shift work and possible GERD.

Keywords: circadian rhythm; gastro-esophageal reflux disease (GERD); meta-analysis; occupational medicine (MeSH); shift work.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Preferred reporting items for systematic reviews and meta-analyses flow chart.
Figure 2
Figure 2
Forest plot of the association between shift work and possible gastro-esophageal reflux disease (GERD) in the 4 studies: a fixed-effect model.
Figure 3
Figure 3
Funnel plot of log-transformed odds ratio of shift work and possible GERD, and standard errors for the 4 studies.
Figure 4
Figure 4
Subgroup analysis of odds ratios of possible GERD based on the style of shift work.
Figure 5
Figure 5
Subgroup analysis of odds ratios of possible GERD based on different genders.
See this image and copyright information in PMC

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