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. 2022 Nov 15;14(11):8183-8190.
eCollection 2022.

Clinical efficacy and safety of flunarizine tablets combined with betahistine hydrochloride tablets in patients with vertebrobasilar insufficiency vertigo

Shanshan Meng  1 , Qin Liu  1 , Liang Zhang  1
Affiliations

Clinical efficacy and safety of flunarizine tablets combined with betahistine hydrochloride tablets in patients with vertebrobasilar insufficiency vertigo

Shanshan Meng et al. Am J Transl Res. .

Abstract

Objective: To explore the clinical efficacy and safety of betahistine hydrochloride tablets in patients with vertebrobasilar insufficiency vertigo (VBIV).

Methods: A total of 133 patients with vertigo caused by vertebrobasilar insufficiency treated in The First People's Hospital of Shangqiu City from March 2019 to August 2021 were selected and analyzed retrospectively. Among them, 63 patients treated with flunarizine tablets were seen as the control group (CG), and 70 with flunarizine tablets combined with betastine hydrochloride tablets were considered as the observation group (OG). The treatment efficacy and adverse reactions were compared, and the vertigo symptom score, quality of life and vertebrobasilar artery hemodynamics were observed before and after treatment.

Results: The effective rate in the OG was higher than that of the CG (P<0.05), but there was no obvious difference in adverse reactions (P>0.05). Compared with the CG, the arterial hemodynamics and cerebral blood perfusion as well as SF-36 score were higher, while the scores of dizziness assessment rating scale (DARS) and dizziness handicap inventory (DHI) scale were lower in the OG (all P<0.05).

Conclusion: Betahistine hydrochloride can effectively improve arterial hemodynamics and cerebral blood flow perfusion in vertebrobasilar insufficiency patients and enhance the clinical efficacy with high safety profile, which is worthy of wide application.

Keywords: Betahistine hydrochloride tablets; clinical efficacy; flunarizine tablets; vertebrobasilar insufficiency vertigo.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of hemodynamics. A. Comparison of blood flow velocity of left vertebral artery before and after treatment. B. Comparison of blood flow velocity of right vertebral artery before and after treatment. C. Comparison of blood flow velocity of basilar artery before and after treatment. D. Comparison of erythrocyte aggregation index before and after treatment. E. Comparison of hematocrit before and after treatment. F. Comparison of whole blood viscosity before and after treatment. *, compared with before treatment (P<0.05), and #, compared with observation group (P<0.05).
Figure 2
Figure 2
Comparison of cerebral blood flow perfusion. A. Comparison of CBF before and after treatment. B. Comparison of CBV before and after treatment. C. Comparison of MTT before and after treatment. *, compared with before treatment (P<0.05); #, compared with observation group (P<0.05).
Figure 3
Figure 3
Comparison of DARS and DHI scores. A. DARS scores before and after treatment. B. DHI scores before and after treatment. *, compared with before treatment (P<0.05); #, compared with observation group (P<0.05).
Figure 4
Figure 4
Comparison of quality of life. A. APF scores before and after treatment. B. RP scores before and after treatment. C. BP scores before and after treatment. D. GH scores before and after treatment. E. VT scores before and after treatment. F. SF scores before and after treatment. G. RE scores before and after treatment. H. MH scores before and after treatment. *, compared with before treatment (P<0.05); #, compared with the observation group (P<0.05).
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