Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov 15;14(11):8002-8008.
eCollection 2022.

The value of Copeptin, myocardial fatty acid-binding protein and myocardial markers in the early diagnosis of acute myocardial infarction

Xin Guan  1 , Tian Liang  2 , Jianyun Fan  1 , Wenyou Yang  1 , Dongliang Wu  2 , Xinguo Li  2
Affiliations

The value of Copeptin, myocardial fatty acid-binding protein and myocardial markers in the early diagnosis of acute myocardial infarction

Xin Guan et al. Am J Transl Res. .

Abstract

Objective: To evaluate and detect the value of Copeptin, myocardial fatty acid binding protein (H-FABP) and myocardial markers in the early diagnosis of acute myocardial infarction (AMI).

Method: A retrospective analysis was carried out in 153 patients with chest pain who came to Xianyang Hospital of Yan'an University from August 2019 to April 2022, of whom 87 patients were finally diagnosed with AMI. Cardiac troponin I (cTnI), Copeptin, and H-FABP levels were measured immediately at the patient's visit. Receiver operating characteristic (ROC) curve was drawn to evaluate and compare the value of Copeptin, H-FABP and cTnI in early diagnosis of AMI and their joint effect in improving the accuracy of early diagnosis of AMI.

Results: (1) The levels of Copeptin, H-FABP and cTnI in AMI patients were evidently higher than those in non-AMI patients with chest pain. (2) The diagnostic sensitivity and specificity of Copeptin were 82.89% and 64.37%, respectively. Those of cTnI were 78.95% and 64.37% respectively, and those of H-FABP were 85.53% and 75.86%, respectively. The AUC size under the ROC curve was H-FABP > hopeptin > cTnI. (3) Joint detection of Copeptin, H-FABP and cTnI was better than mono-detection in early diagnosis of AMI.

Conclusion: H-FABP has high accuracy in detecting early AMI, which is better than cTnI and Copeptin, but the joint detection of the three is of the highest value.

Keywords: Copeptin; acute myocardial infarction; cardiac fatty acid-binding protein; cardiac troponin I; early diagnosis.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

Figure 1
Figure 1
The diagnostic value of serum H-FABP, Copeptin and cTnI in early AMI. A. ROC curve of H-FABP for early AMI. B. ROC curve of Copeptin for early AMI. C. ROC curve of cTnI on early AMI. D. Diagnostic value of joint detection of serum H-FABP, Copeptin and cTnI in early AMI. H-FABP: Myocardial Fatty Acid Binding Protein; AMI: Acute Myocardial Infarction.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Zeymer U. Diagnosis and initial management of acute myocardial infarction. MMW Fortschr Med. 2019;161:34–36. - PubMed
    1. Stengaard C, Sorensen JT, Rasmussen MB, Botker MT, Pedersen CK, Terkelsen CJ. Prehospital diagnosis of patients with acute myocardial infarction. Diagnosis (Berl) 2016;3:155–166. - PubMed
    1. Edupuganti MM, Ganga V. Acute myocardial infarction in pregnancy: current diagnosis and management approaches. Indian Heart J. 2019;71:367–374. - PMC - PubMed
    1. DeFilippis AP, Chapman AR, Mills NL, de Lemos JA, Arbab-Zadeh A, Newby LK, Morrow DA. Assessment and treatment of patients with type 2 myocardial infarction and acute nonischemic myocardial injury. Circulation. 2019;140:1661–1678. - PMC - PubMed
    1. Wang XY, Zhang F, Zhang C, Zheng LR, Yang J. The biomarkers for acute myocardial infarction and heart failure. Biomed Res Int. 2020;2020:2018035. - PMC - PubMed

LinkOut - more resources