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. 2022 Nov 15;14(11):8175-8182.
eCollection 2022.

Patterns of essential trace elements (Cr, Mn, Ni, and Se) in Saudi patients with type 2 diabetes mellitus

Sobhy Yakout  1 , Fatimah Faqeeh  1 , Omar Al-Attas  1 , Syed Danish Hussain  1 , Gamal M Saadawy  1 , Nasser M Al-Daghri  1 , Majed S Alokail  1
Affiliations

Patterns of essential trace elements (Cr, Mn, Ni, and Se) in Saudi patients with type 2 diabetes mellitus

Sobhy Yakout et al. Am J Transl Res. .

Abstract

Objectives: Type 2 diabetes mellitus (T2DM) outcomes were observed to be influenced by circulating trace elements' status. The differences and correlations between serum levels of chromium (Cr), manganese (Mn), nickel (Ni), and selenium (Se) in Saudi patients with and without T2DM as well as those with prediabetes (pre-DM) were examined in this retrospective cross-sectional study.

Methods: Anthropometrics and fasting blood samples were collected from 119 patients with T2DM (aged 41-64 years), 95 non-T2DM (aged 27-55 years), and 80 with pre-DM (aged 35-57 years). An inductively coupled plasma-mass spectrometer was used to measure trace minerals in the blood.

Results: T2DM patients had significantly lower Mn serum concentrations than controls. There was no difference in Cr and Ni levels between groups. Serum Mn and Ni levels were lower in pre-DM subjects than controls. Serum Se concentrations were higher in pre-DM and T2DM patients than controls. In T2DM patients, serum Cr and Mn levels were inversely correlated with glucose, while Ni and Se levels were positively correlated with glucose in the T2DM group.

Conclusions: Because of their roles in glucose metabolism, impaired trace element status may also play a role in T2DM pathogenesis. Appropriate dietary control and mineral supplementation are recommended.

Keywords: Saudi; Type 2 diabetes; trace elements.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Correlation between glucose (mmol/l) and Cr (µg/l) in T2DM and pre-DM patients. Type 2 Diabetes Mellitus (T2DM).
Figure 2
Figure 2
Correlation between glucose (mmol/l) and Mn (µg/l) in T2DM and pre-DM patients. Type 2 Diabetes Mellitus (T2DM), Manganese (Mn).
Figure 3
Figure 3
Correlation between glucose (mmol/l) and Ni (µg/l) in T2DM and pre-DM patients. Type 2 Diabetes Mellitus (T2DM), Nickel (Ni).
Figure 4
Figure 4
Correlation between glucose (mmol/l) and Se (µg/l) in T2DM and pre-DM patients. Type 2 Diabetes Mellitus (T2DM), and Selenium (Se).
See this image and copyright information in PMC

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