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Review
. 2022 Nov 25:12:1019750.
doi: 10.3389/fonc.2022.1019750. eCollection 2022.

Emerging roles of alternative RNA splicing in oral squamous cell carcinoma

Miaomiao Liu  1 , Jihua Guo  1   2 , Rong Jia  1   3
Affiliations
Review

Emerging roles of alternative RNA splicing in oral squamous cell carcinoma

Miaomiao Liu et al. Front Oncol. .

Abstract

Alternative RNA splicing (ARS) is an essential and tightly regulated cellular process of post-transcriptional regulation of pre-mRNA. It produces multiple isoforms and may encode proteins with different or even opposite functions. The dysregulated ARS of pre-mRNA contributes to the development of many cancer types, including oral squamous cell carcinoma (OSCC), and may serve as a biomarker for the diagnosis and prognosis of OSCC and an attractive therapeutic target. ARS is mainly regulated by splicing factors, whose expression is also often dysregulated in OSCC and involved in tumorigenesis. This review focuses on the expression and roles of splicing factors in OSCC, the alternative RNA splicing events associated with OSCC, and recent advances in therapeutic approaches that target ARS.

Keywords: OSCC; alternative splicing; splicing factor; therapeutic targets; tumor progression.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The common types of alternative RNA splicing and the SF3b complex involved in alternative RNA splicing. (A) The different types of alternative RNA splicing and transcript variants (exon skipping, intron retention, mutually exclusive exons, alternative 5’ splice site, and alternative 3’ splice site). (B) Diagram of the components of spliceosome complex, especially SF3b complex, and SF3b1-specific inhibitors.
Figure 2
Figure 2
Alternative RNA splicing and splicing factors regulate OSCC cell proliferation, invasion, and EMT.
See this image and copyright information in PMC

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