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Review
. 2022 Nov 24:12:1031802.
doi: 10.3389/fonc.2022.1031802. eCollection 2022.

Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions

Bowen Liu  1 , Chengbin Dong  1 , Quan Chen  1 , Zhenhua Fan  1 , Yu Zhang  1 , Yifan Wu  1 , Ting Cui  1 , Fuquan Liu  1
Affiliations
Review

Circ_0007534 as new emerging target in cancer: Biological functions and molecular interactions

Bowen Liu et al. Front Oncol. .

Abstract

Circular RNA (circRNAs), an important member of the non-coding RNA (ncRNA) family, are widely expressed in a variety of biological cells. Owing to their stable structures, sequence conservations, and cell- or tissue-specific expressions, these RNA have become a popular subject of scientific research. With the development of sequencing methods, it has been revealed that circRNAs exert their biological function by sponging microRNAs (miRNAs), regulating transcription, or binding to proteins. Humans have historically been significantly impacted by various types of cancer. Studies have shown that circRNAs are abnormally expressed in various cancers and are involved in the occurrence and development of malignant tumors, such as tumor cell proliferation, migration, and invasion. As one of its star molecules, circ_0007534 is upregulated in colorectal, cervical, and pancreatic cancers; is closely related to the occurrence, development, and prognosis of tumors; and is expected to become a novel tumor marker and therapeutic target. This article briefly reviews the expression and mechanism of circ_0007534 in malignant tumors based on the domestic and foreign literature.

Keywords: circRNA; circ_0007534; expression; migration; proliferation; tumor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.

Figures

Figure 1
Figure 1
A three-dimensional cluster map of circRNA or circular RNA studies over the past decades, retrieved from PubMed.
Figure 2
Figure 2
Mechanisms of circ_0007534 regulating various cancers.
See this image and copyright information in PMC

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References

    1. Bray F, Parkin DM. Cancer in Sub-Saharan Africa in 2020: A review of current estimates of the national burden, data gaps, and future needs. Lancet Oncol (2022) 23(6):719–28. doi: 10.1016/s1470-2045(22)00270-4 - DOI - PubMed
    1. Dyba T, Randi G, Bray F, Martos C, Giusti F, Nicholson N, et al. . The European cancer burden in 2020: Incidence and mortality estimates for 40 countries and 25 major cancers. Eur J Cancer (2021) 157:308–47. doi: 10.1016/j.ejca.2021.07.039 - DOI - PMC - PubMed
    1. Soerjomataram I, Bray F. Planning for tomorrow: Global cancer incidence and the role of prevention 2020-2070. Nat Rev Clin Oncol (2021) 18(10):663–72. doi: 10.1038/s41571-021-00514-z - DOI - PubMed
    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: Globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin (2018) 68(6):394–424. doi: 10.3322/caac.21492 - DOI - PubMed
    1. Tang B, Zhu J, Zhao Z, Lu C, Liu S, Fang S, et al. . Diagnosis and prognosis models for hepatocellular carcinoma patient's management based on tumor mutation burden. J Adv Res (2021) 33:153–65. doi: 10.1016/j.jare.2021.01.018 - DOI - PMC - PubMed