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Review
. 2022 Nov 24:10:1073320.
doi: 10.3389/fcell.2022.1073320. eCollection 2022.

Matricellular proteins in cutaneous wound healing

Claudia Griselda Cárdenas-León  1 , Kristina Mäemets-Allas  1 , Mariliis Klaas  1 , Heli Lagus  2 , Esko Kankuri  3 , Viljar Jaks  1   4
Affiliations
Review

Matricellular proteins in cutaneous wound healing

Claudia Griselda Cárdenas-León et al. Front Cell Dev Biol. .

Abstract

Cutaneous wound healing is a complex process that encompasses alterations in all aspects of the skin including the extracellular matrix (ECM). ECM consist of large structural proteins such as collagens and elastin as well as smaller proteins with mainly regulative properties called matricellular proteins. Matricellular proteins bind to structural proteins and their functions include but are not limited to interaction with cell surface receptors, cytokines, or protease and evoking a cellular response. The signaling initiated by matricellular proteins modulates differentiation and proliferation of cells having an impact on the tissue regeneration. In this review we give an overview of the matricellular proteins that have been found to be involved in cutaneous wound healing and summarize the information known to date about their functions in this process.

Keywords: Skin; extracellular matrix; non-structural matrix proteins; re-epithelialization; regeneration.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The concept of matricellular proteins. The blue and gold arrows represent upregulation and downregulation, respectively.
FIGURE 2
FIGURE 2
A timeline of cutaneous wound healing (Reinke and Sorg, 2012) in connection with the timing of the expression of matricellular proteins (arrows) (modified, from Midwood et al., 2004).
See this image and copyright information in PMC

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