Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Nov 24:13:981063.
doi: 10.3389/fphar.2022.981063. eCollection 2022.

Application of herbal traditional Chinese medicine in the treatment of lupus nephritis

Liu Liu  1 , Lei Zhang  1 , Ming Li  1
Affiliations
Review

Application of herbal traditional Chinese medicine in the treatment of lupus nephritis

Liu Liu et al. Front Pharmacol. .

Abstract

Lupus nephritis (LN) is a secondary renal disease caused by systemic lupus erythematosus affecting the kidneys. It is one of the main causes of end-stage renal disease and a serious risk factor for early mortality and disability of systemic lupus erythematosus patients. Existing LN treatment is mainly based on hormones, cytotoxic drugs, and biological agents. Nevertheless, the prognosis of LN patients remains poor because of frequent recurrence and exacerbation of adverse drug reactions. Hence, LN is still the most important cause of end-stage renal disease. In recent years, traditional Chinese medicine (TCM) has attracted increasing attention because of encouraging evidence that it alleviates LN and the well-described mechanisms underlying renal injury. TCM has therapeutic benefits for treating LN patients. This review article elucidates TCM preparations, TCM monomers, and herbal or natural extraction for LN treatment to provide effective supplementary evidence for promoting the development of TCM treatment for LN and reference for future research and clinical practice.

Keywords: inflammation; kidney injury; lupus nephritis (LN); therapy; traditional Chinese medicine.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Summary of the role of TCM Preparations in the treatment of lupus nephritis.
FIGURE 2
FIGURE 2
Summary of the role of TCM monomers and herbal or natural extracts in the treatment of lupus nephritis.
See this image and copyright information in PMC

References

    1. Aldieri E., Atragene D., Bergandi L., Riganti C., Costamagna C., Bosia A., et al. (2003). Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation. FEBS Lett. 552 (2-3), 141–144. 10.1016/s0014-5793(03)00905-0 - DOI - PubMed
    1. Anders H. J., Saxena R., Zhao M. H., Parodis I., Salmon J. E., Mohan C. (2020). Lupus nephritis. Nat. Rev. Dis. Prim. 6 (1), 7. 10.1038/s41572-019-0141-9 - DOI - PubMed
    1. Balkrishna A., Thakur P., Singh S., Chandra Dev S. N., Varshney A. (2020). Mechanistic paradigms of natural plant metabolites as remedial candidates for systemic lupus erythromatosus. Cells 9 (4), E1049. 10.3390/cells9041049 - DOI - PMC - PubMed
    1. Barido F. H., Jang A., Pak J. I., Kim D. Y., Lee S. K. (2020). Investigation of taste-related compounds and antioxidative profiles of retorted samgyetang made from fresh and dried cordyceps militaris mushrooms. Food Sci. Anim. Resour. 40 (5), 772–784. 10.5851/kosfa.2020.e53 - DOI - PMC - PubMed
    1. Bruschi M., Moroni G., Sinico R. A., Franceschini F., Fredi M., Vaglio A., et al. (2021). Neutrophil extracellular traps in the autoimmunity context. Front. Med. 8, 614829. 10.3389/fmed.2021.614829 - DOI - PMC - PubMed

LinkOut - more resources