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. 2022 Nov 29;9(11):003586.
doi: 10.12890/2022_003586. eCollection 2022.

Spontaneous Resolution of a Pulmonary Cystic Amyloidosis Mass

Nouha Guediri  1 , Islam Mejri  1 , Nouha Boubaker  1 , Samira Mhamdi  1 , Selsabil Daboussi  1 , Chiraz Aichaouia  1 , Houssem Messaoudi  2 , Aida Ayadi  3 , Zied Moatemri  1
Affiliations

Spontaneous Resolution of a Pulmonary Cystic Amyloidosis Mass

Nouha Guediri et al. Eur J Case Rep Intern Med. .

Abstract

Introduction: Amyloidosis is a rare illness characterized by the deposition in organs of amyloid, which can be detected by histological staining. Amyloidosis restricted to the lower respiratory tract is unusual.

Results: We reported the case of a 68-year-old woman with no history of chronic diseasewho presented with dyspnoea on exertion, cough and fatigue. The physical examination was unremarkable. A CT scan showed a cystic mass with a thickened wall in the apical segment of the left lower lobe. A biopsy of the mass was performed, and histological and immunohistochemical study confirmed the diagnosis of AL amyloidosis. The patient's clinical and radiological symptoms spontaneously improved without treatment after 3 years.

Conclusion: Amyloid-related cystic lung disease is a rare presentation of amyloidosis in the thorax. More case reports are required to determine if such masses can resolve without treatment and whether amyloid-associated cystic lung disease actually exists.

Learning points: Dyspnoea and cough are a rare atypical presentation that can reveal pulmonary amyloidosis.A cystic lung mass should raise suspicion for pulmonary amyloidosis.Clinical symptoms and radiological findings of a cystic mass spontaneously resolved without treatment after 3 years in this patient with pulmonary amyloidosis.

Keywords: Amyloidosis; lung; pulmonary cystic mass.

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Conflict of interest statement

Conflicts of Interests: The authors declare there are no competing interests.

Figures

Figure 1
Figure 1
CT image of the chest showing a cystic mass with a thickened wall in the apical segment of the left lower lobe
Figure 2
Figure 2
(A) Lung parenchyma with abundant amorphous interstitial deposits, coloured brick red by Congo red; (B) lung parenchyma under polarized light with apple-green birefringence confirming amyloidosis
See this image and copyright information in PMC

References

    1. Baker KR, Rice L. The amyloidoses: clinical features, diagnosis and treatment. Methodist DeBakey Cardiovasc J. 2012;8(3):3–7. - PMC - PubMed
    1. Sipe JD, Benson MD, Buxbaum JN, Ikeda S-I, Merlini G, Saraiva MJM, et al. Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis. Amyloid. 2014;21(4):221–224. - PubMed
    1. Yakupova EI, Bobyleva LG, Vikhlyantsev IM, Bobylev AG. Congo Red and amyloids: history and relationship. Biosci Rep. 2019;39(1):BSR20181415. - PMC - PubMed
    1. Mohammadien HA, Morsi SN, Al Shahat MA. Systemic AL amyloidosis presenting with diffuse alveolar septal involvement and respiratory failure: a case report and review of the literature. Egypt J Bronchol. 2021;15(1):1–9.
    1. Cordier JF, Loire R, Brune J. Amyloidosis of the lower respiratory tract: clinical and pathologic features in a series of 21 patients. Chest. 1986;90(6):827–831. - PubMed

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