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. 2023:2592:21-36.
doi: 10.1007/978-1-0716-2807-2_2.

Uncommon Transplantation Sites: Transplantation of Islets and Islet Organoids in the Anterior Chamber of the Eye of Rodents and Monkeys

Tilo Moede  1 , Sai Bo Bo Tun  1   2 , Ingo B Leibiger  1 , Per-Olof Berggren  3   4   5
Affiliations

Uncommon Transplantation Sites: Transplantation of Islets and Islet Organoids in the Anterior Chamber of the Eye of Rodents and Monkeys

Tilo Moede et al. Methods Mol Biol. 2023.

Abstract

The anterior chamber of the eye is a highly vascularized and innervated location that is also particularly rich in oxygen and immune privileged. This uncommon transplantation site offers unique possibilities for the observation of the transplanted material as well as for local pharmacological intervention. Transplantation of islets and islet organoids to the anterior chamber of the eye of mice and monkeys facilitates a multitude of new approaches for research into islet physiology and pathophysiology and for the treatment of diabetes. We now present a short overview of the experimental possibilities and describe an updated protocol for transplantation of islets and islet organoids into mice and monkeys.

Keywords: Islet; Islet organoids; Monkey; Mouse; Nonhuman primate; Rodent; Transplantation.

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