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. 2023 Jan;19(1):37-39.
doi: 10.1007/s13181-022-00921-3. Epub 2022 Dec 12.

Vaping THC-O Acetate: Potential for Another EVALI Epidemic

Neal L Benowitz  1   2 , Christopher Havel  3   4 , Peyton Jacob  3   4 , Donal F O'Shea  5 , Dan Wu  5 , Jefferson Fowles  6
Affiliations

Vaping THC-O Acetate: Potential for Another EVALI Epidemic

Neal L Benowitz et al. J Med Toxicol. 2023 Jan.
No abstract available

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
Potential sources of ketene formation from commercial vaping products.
Fig. 2
Fig. 2
Calculated energy profiles for the pyrolysis of acetate substrates via concerted [1, 3] hydrogen shift mechanism using gas-phase M06-2X/6–311G (d,p) basis set. A Relative free energies (kcal mol−1) for starting materials, transition states, and products formed for the pyrolysis of VEA3 (black) and Δ8-THC-O-acetate (red) leading to the elimination of ketene. B Optimized geometry for the TS corresponding to the pyrolysis of Δ8-THC-O-acetate, leading to the elimination of ketene. Simplified structures used for THC calculations without C4H9 alkyl group.
See this image and copyright information in PMC

References

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