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. 2023 Feb 1;29(2):328-331.
doi: 10.1093/ibd/izac251.

Environmental Interaction of Resolved Human Cytomegalovirus Infection With Crohn's Disease Location

Terri Shih  1 , Susy Yusung  1 , Rivkah Gonsky  2 , Rhiannon Dutra-Clarke  2 , David Ziring  2 , Shervin Rabizadeh  2 , Subra Kugathasan  3 , Lee A Denson  4 , Dalin Li  2 , Jonathan Braun  2
Affiliations

Environmental Interaction of Resolved Human Cytomegalovirus Infection With Crohn's Disease Location

Terri Shih et al. Inflamm Bowel Dis. .
No abstract available

Keywords: HLA; KIR; cytomegalovirus; inflammatory bowel disease.

Plain language summary

Active cytomegalovirus (CMV) infection complicates management of inflammatory bowel disease, but the relationship of resolved CMV infection to Crohn’s disease (CD) behavior or localization is unknown. This article reports a striking risk (9-fold) of Crohn’s disease localization to the colon with prior CMV infection. It also reports imputed mucosal cellular composition, HLA class 1, and KIR gene variants that delimit prior observations regarding HLA and KIR associations with Crohn’s disease risk and behavior.

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References

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