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Meta-Analysis
. 2022 Dec 12;17(12):e0278919.
doi: 10.1371/journal.pone.0278919. eCollection 2022.

Prevalence of prediabetes and type 2 diabetes mellitus in south and southeast Asian women with history of gestational diabetes mellitus: Systematic review and meta-analysis

Chockalingam Shivashri  1   2 , Wesley Hannah  2 , Mohan Deepa  2 , Yonas Ghebremichael-Weldeselassie  1   3 , Ranjit Mohan Anjana  2 , Ram Uma  4 , Viswanathan Mohan  2 , Ponnusamy Saravanan  1   5
Affiliations
Meta-Analysis

Prevalence of prediabetes and type 2 diabetes mellitus in south and southeast Asian women with history of gestational diabetes mellitus: Systematic review and meta-analysis

Chockalingam Shivashri et al. PLoS One. .

Erratum in

Abstract

Background: The burden of Gestational Diabetes Mellitus (GDM) is very high in south Asia (SA) and southeast Asia (SEA). Thus, there is a need to understand the prevalence and risk factors for developing prediabetes and type 2 diabetes mellitus (T2DM) postpartum, in this high-risk population.

Aim: To conduct a systematic review and meta-analysis to estimate the prevalence of prediabetes and T2DM among the women with history of GDM in SA and SEA.

Methods: A comprehensive literature search was performed in the following databases: Medline, EMBASE, Web of Knowledge and CINHAL till December 2021. Studies that had reported greater than six weeks of postpartum follow-up were included. The pooled prevalence of diabetes and prediabetes were estimated by random effects meta-analysis model and I2 statistic was used to assess heterogeneity.

Results: Meta-analysis of 13 studies revealed that the prevalence of prediabetes and T2DM in post-GDM women were 25.9% (95%CI 18.94 to 33.51) and 29.9% (95%CI 17.02 to 44.57) respectively. Women with history of GDM from SA and SEA seem to have higher risk of developing T2DM than women without GDM (RR 13.2, 95%CI 9.52 to 18.29, p<0.001). The subgroup analysis showed a rise in the prevalence of T2DM with increasing duration of follow-up.

Conclusion: The conversion to T2DM and prediabetes is very high among women with history of GDM in SA and SEA. This highlights the need for follow-up of GDM women for early identification of dysglycemia and to plan interventions to prevent/delay the progression to T2DM.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. PRISMA flow diagram showing the study selection process.
Fig 2
Fig 2
Prevalence of (a) prediabetes and (b)T2DM in women with history of GDM in SA and SEA.
Fig 3
Fig 3
Prevalence of (a) prediabetes and (b) T2DM based on the follow-up period.
See this image and copyright information in PMC

References

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