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. 2023 Feb;93(3):466-468.
doi: 10.1038/s41390-022-02411-2. Epub 2022 Dec 12.

Is epinephrine effective during neonatal resuscitation?

Deepika Sankaran  1   2 , Eleanor J Molloy  3 , Satyan Lakshminrusimha  4
Affiliations

Is epinephrine effective during neonatal resuscitation?

Deepika Sankaran et al. Pediatr Res. 2023 Feb.

Abstract

In the original research article published in Pediatric Research, Anderson et al provide valuable data from a placebo-controlled randomized trial on epinephrine in 12-hour-old piglets in cardiac arrest. In this commentary, we discuss briefly the existing evidence supporting use of epinephrine during neonatal resuscitation.

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Conflict of interest statement

Disclosure: The named authors have no conflict of interest, financial or otherwise. Dr. Satyan Lakshminrusimha is a member of the American Academy of Pediatrics (AAP), Neonatal Resuscitation Steering Committee (NRP). Views expressed in this manuscript are those of authors and do not reflect the official position of AAP/NRP.

Figures

Figure 1:
Figure 1:
Differences between postnatal piglet (left) and perinatal lamb (right) models of asphyxial cardiac arrest.
See this image and copyright information in PMC

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References

    1. Wyckoff MH, Weiner GM & Neonatal Life Support, C. 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Pediatrics (2020). - PubMed
    1. Halling C, Sparks JE, Christie L & Wyckoff MH Efficacy of Intravenous and Endotracheal Epinephrine During Neonatal Cardiopulmonary Resuscitation in the Delivery Room. The Journal of pediatrics 185, 232–236 (2017). - PubMed
    1. Andersen HB et al. Epinephrine Vs Placebo in Neonatal Resuscitation: Rosc and Brain Mrs/Mri in Term Piglets. Pediatr Res (2022). - PubMed
    1. Barber CA & Wyckoff MH Use and Efficacy of Endotracheal Versus Intravenous Epinephrine During Neonatal Cardiopulmonary Resuscitation in the Delivery Room. Pediatrics 118, 1028–1034 (2006). - PubMed
    1. Vali P et al. Evaluation of Timing and Route of Epinephrine in a Neonatal Model of Asphyxial Arrest. Journal of the American Heart Association 6 (2017). - PMC - PubMed

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