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Comment
. 2023 Feb;24(2):69.
doi: 10.1038/s41576-022-00565-7.

CHIPping away at the genetic aetiology of clonal haematopoiesis

Kirsty Minton  1
Affiliations
Comment

CHIPping away at the genetic aetiology of clonal haematopoiesis

Kirsty Minton. Nat Rev Genet. 2023 Feb.

Abstract

A study in Nature reports the identification of new germline variants associated with particular subtypes of clonal haematopoiesis of indeterminate potential (CHIP) and their links to different health outcomes.

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Comment on

  • Common and rare variant associations with clonal haematopoiesis phenotypes.
    Kessler MD, Damask A, O'Keeffe S, Banerjee N, Li D, Watanabe K, Marketta A, Van Meter M, Semrau S, Horowitz J, Tang J, Kosmicki JA, Rajagopal VM, Zou Y, Houvras Y, Ghosh A, Gillies C, Mbatchou J, White RR, Verweij N, Bovijn J, Parikshak NN, LeBlanc MG, Jones M; Regeneron Genetics Center; GHS-RGC DiscovEHR Collaboration; Glass DJ, Lotta LA, Cantor MN, Atwal GS, Locke AE, Ferreira MAR, Deering R, Paulding C, Shuldiner AR, Thurston G, Ferrando AA, Salerno W, Reid JG, Overton JD, Marchini J, Kang HM, Baras A, Abecasis GR, Jorgenson E. Kessler MD, et al. Nature. 2022 Dec;612(7939):301-309. doi: 10.1038/s41586-022-05448-9. Epub 2022 Nov 30. Nature. 2022. PMID: 36450978 Free PMC article.

References

Original article

    1. Kessler MD, et al. Common and rare variant associations with clonal haematopoiesis phenotypes. Nature. 2022 doi: 10.1038/s41586-022-05448-9. - DOI - PMC - PubMed

Related article

    1. Silver AJ, Bick AG, Savona MR. Germline risk of clonal haematopoiesis. Nat. Rev. Genet. 2021;22:603–617. doi: 10.1038/s41576-021-00356-6. - DOI - PMC - PubMed

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