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Review
. 2023 Jun;173(9-10):221-226.
doi: 10.1007/s10354-022-00979-2. Epub 2022 Dec 13.

[Gastroenteropancreatic neuroendocrine tumors : (GEP-NENs)]

[Article in German]
Christian Sebesta  1 , Alexandra Feichter  2 , Flonza Selimi  1
Affiliations
Review

[Gastroenteropancreatic neuroendocrine tumors : (GEP-NENs)]

[Article in German]
Christian Sebesta et al. Wien Med Wochenschr. 2023 Jun.

Abstract
in English, German

The entity of NENs represent a highly heterogenous group of malignancies that require a multidisciplinary approach during the treatment of patients. The following article aims to provide a concise overview of the current state of the art in diagnostics and therapy. One specific feature of G1/G2 NENs is that the indication for surgery is given even in metastatic settings. Specific details regarding the treatment of its various different subgroups need to be gathered from available guidelines or current clinical studies. The field of nuclear medicine offers promising options for diagnostics and therapy which needs further investigation.

NENs stellen aufgrund ihrer Heterogenität und ihres Anspruches auf multidisziplinäre Behandlung eine Herausforderung für die Betreuung betroffener Patienten dar. Der vorliegende Artikel zielt darauf ab, einen konzisen Überblick über den aktuellen Stand in Diagnostik und Therapie zu bieten. Eine Spezifität von NENs stellt die breite Empfehlung der chirurgische Resektion von G1/G2 NENs, selbst bis in metastasierte Stadien, dar. Details zu konkreten Therapieoptionen bzw. zu den Therapien der diversen Subgruppen sind den entsprechenden Leitlinien bzw. Studien zu entnehmen. Nuklearmedizinische Möglichkeiten im Bereich der Diagnostik und Therapie bieten neue vielversprechenden Optionen, die noch weiter in Studien ergründet werden müssen.

Keywords: Carcinoid; Gastrinoma; Insulinoma; Merkel-cell carcinoma; Multiple endocrine neoplasia (MEN); Zollinger-Ellison syndrome.

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References

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