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Comment
. 2022 Dec 12;40(12):1454-1456.
doi: 10.1016/j.ccell.2022.11.012.

Less, but better: A simplified design for T cell redirection and conditional payload delivery

Korbinian N Kropp  1 , Christopher A Klebanoff  2
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Free article
Comment

Less, but better: A simplified design for T cell redirection and conditional payload delivery

Korbinian N Kropp et al. Cancer Cell. .
Free article

Abstract

Combining immune receptor engineering with conditional expression of accessory molecules holds great promise for advancing the field of cell-based immunotherapies. In this issue of Cancer Cell, Smole et al. introduce a modular single vector system to simultaneously redirect T cell specificity toward cancer antigens while achieving activation-gated delivery of customizable payloads.

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Conflict of interest statement

Declaration of interests C.A.K. is on the scientific and/or clinical advisory boards for Achilles Therapeutics, Aleta BioTherapeutics, Bellicum Pharmaceuticals, Catamaran Bio, Obsidian Therapeutics, and T-knife; has consulted for Bristol Myers Squibb, Decheng Capital, PACT Pharma, and Roche/Genentech; and has patents broadly related to cell and gene therapy outside the scope of this work.

Comment on

  • Expression of inducible factors reprograms CAR-T cells for enhanced function and safety.
    Smole A, Benton A, Poussin MA, Eiva MA, Mezzanotte C, Camisa B, Greco B, Sharma P, Minutolo NG, Gray F, Bear AS, Baroja ML, Cummins C, Xu C, Sanvito F, Goldgewicht AL, Blanchard T, Rodriguez-Garcia A, Klichinsky M, Bonini C, June CH, Posey AD Jr, Linette GP, Carreno BM, Casucci M, Powell DJ Jr. Smole A, et al. Cancer Cell. 2022 Dec 12;40(12):1470-1487.e7. doi: 10.1016/j.ccell.2022.11.006. Cancer Cell. 2022. PMID: 36513049 Free PMC article.

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