Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Dec 15;387(24):e65.
doi: 10.1056/NEJMc2212542.

Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19. Reply

Carolyn T Bramante  1 , John B Buse  2 , David R Boulware  3
Affiliations
Comment

Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19. Reply

Carolyn T Bramante et al. N Engl J Med. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Since publication of their article, the authors report no further potential conflict of interest.

Comment on

  • Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19.
    Bramante CT, Huling JD, Tignanelli CJ, Buse JB, Liebovitz DM, Nicklas JM, Cohen K, Puskarich MA, Belani HK, Proper JL, Siegel LK, Klatt NR, Odde DJ, Luke DG, Anderson B, Karger AB, Ingraham NE, Hartman KM, Rao V, Hagen AA, Patel B, Fenno SL, Avula N, Reddy NV, Erickson SM, Lindberg S, Fricton R, Lee S, Zaman A, Saveraid HG, Tordsen WJ, Pullen MF, Biros M, Sherwood NE, Thompson JL, Boulware DR, Murray TA; COVID-OUT Trial Team. Bramante CT, et al. N Engl J Med. 2022 Aug 18;387(7):599-610. doi: 10.1056/NEJMoa2201662. N Engl J Med. 2022. PMID: 36070710 Free PMC article. Clinical Trial.
  • Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19.
    Shukla AK, Misra S. Shukla AK, et al. N Engl J Med. 2022 Dec 15;387(24):e65. doi: 10.1056/NEJMc2212542. N Engl J Med. 2022. PMID: 36516099 No abstract available.

References

    1. Pocock SJ, Stone GW. The primary outcome fails — what next? N Engl J Med 2016;375:861–70. - PubMed
    1. Manson JE, Cook NR, Lee I-M, et al. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med 2019;380:33–44. - PMC - PubMed
    1. Manson JE, Cook NR, Lee IM, et al. Marine n–3 fatty acids and prevention of cardiovascular disease and cancer. N Engl J Med 2019;380:23–32. - PMC - PubMed
    1. Jitobaom K, Boonarkart C, Manopwisedjaroen S, et al. Synergistic anti-SARS-CoV-2 activity of repurposed anti-parasitic drug combinations. BMC Pharmacol Toxicol 2022;23:41. - PMC - PubMed

LinkOut - more resources