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Comment
. 2022 Dec 13;55(12):2225-2227.
doi: 10.1016/j.immuni.2022.11.010.

IRF2 integrates inflammatory signals to balance T cell exhaustion

Amania A Sheikh  1 , Daniel T Utzschneider  2
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IRF2 integrates inflammatory signals to balance T cell exhaustion

Amania A Sheikh et al. Immunity. .
Free article

Abstract

The transcription factor interferon regulatory factor 2 (IRF2) translates interferon signaling to regulate T cells. In this issue of Immunity, Lukhele et al. identify IRF2 in tumor-infiltrating T cells as a sensor for extrinsic signals that drives an exhaustion program.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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