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Review
. 2022 Dec 14;31(166):220123.
doi: 10.1183/16000617.0123-2022. Print 2022 Dec 31.

Severe community-acquired pneumonia

Michael S Niederman  1   2 , Antoni Torres  3   2
Affiliations
Review

Severe community-acquired pneumonia

Michael S Niederman et al. Eur Respir Rev. .

Abstract

Severe community-acquired pneumonia is the most life-threatening form of community-acquired pneumonia, characterised by intensive care unit admission and high morbidity and mortality. In this review article, we cover in depth six aspects of severe community-acquired pneumonia that are still controversial: use of PCR molecular techniques for microbial diagnosis; the role of biomarkers for initial management; duration of treatment, macrolides or quinolones in the initial empirical antibiotic therapy; the use of prediction scores for drug-resistant pathogens to modify initial empiric therapy; the use of noninvasive mechanical ventilation and high-flow nasal oxygen; and the use of corticosteroids as adjunctive therapy in severe community-acquired pneumonia.

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Conflict of interest statement

Conflicts of interest: M.S. Niederman has received grants or contracts from Shionogi, Merck and Bayer; and consulting fees from Pfizer, Merck, Shionogi, Bayer, Thermo Fisher and Nabriva, outside the submitted work. He also reports participation on a Data Safety Monitoring Board or Advisory Board for Fab'entec. Conflicts of interest: A. Torres is a current Editorial Board member for the European Respiratory Review and reports consulting fees from Pfizer, Poliphor, MSD and Jansen OM Pharma; and payment or honoraria for lectures, presentations, speakers’ bureaus, manuscript writing or educational events from Pfizer, Poliphor, MSD and Jansen OM Pharma, outside the submitted work.

Comment in

  • doi: 10.1183/16000617.0150-2022

References

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