Outcomes of liver resection for huge hepatocellular carcinoma exceeding 10 cm in size: A single center experience

Abstract

Background: To evaluate our experience of resection for huge hepatocellular carcinoma (HCC) (exceeding 10 cm in diameter).

Methods: We reviewed the patients' data who underwent liver resection for huge HCC between 2010 and 2019. We divided them into two groups according to liver resection extent (minor/major).

Results: 40 patients were included. Minor Group included 19 patients (47.5%), and Major Group included 21 patients (52.5%). Longer operation time, hospital stay, and more severe complications were found in Major Group. The 1-, 3-, and 5-years OS rates were 76.6%, 39.5%, and 39.5%, respectively. The 1-, 3-, and 5-year DFS rates were 65.6%, 40%, and 0%, respectively. There were no significant differences between the two groups regarding OS (p = 0.598) and DFS (p = 0.564).

Conclusion: Liver resection for huge HCC is associated with average morbidities and mortality. Proper selection, adequate techniques and standardized care can provide favorable patients' survival.

Keywords: Hepatocellular carcinoma; Large tumor; Liver resection; Survival.