Molecular docking analysis of metformin analogues with GSK-3β

Ponnu Lakshmi Rajagopal¹, Vidhya Rekha Umapathy², Sandhya P³, Fathima Jh⁴, Ramajayam Govindan⁵, Chella Perumal Palanisamy⁶, Vishnu Priya Veeraraghavan⁷, Selvaraj Jayaraman⁷

Affiliations

¹ Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, India.
² Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India.
³ Department of Biochemistry, Allied Health science, Dr. M.G.R Educational and Research Institute, Chennai India.
⁴ Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, India.
⁵ Multi Disciplinary Research Unit, Madurai Medical College, TamilNadu, India.
⁶ State Key Laboratory of Bio-based Materials and Green Papermaking, College of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China.
⁷ Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

PMID: 36518134
PMCID: PMC9722410
DOI: 10.6026/97320630018269

Molecular docking analysis of metformin analogues with GSK-3β

Ponnu Lakshmi Rajagopal et al. Bioinformation. 2022.

. 2022 Mar 31;18(3):269-272.

doi: 10.6026/97320630018269. eCollection 2022.

Authors

Ponnu Lakshmi Rajagopal¹, Vidhya Rekha Umapathy², Sandhya P³, Fathima Jh⁴, Ramajayam Govindan⁵, Chella Perumal Palanisamy⁶, Vishnu Priya Veeraraghavan⁷, Selvaraj Jayaraman⁷

Affiliations

¹ Central Research Laboratory, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, India.
² Department of Public Health Dentistry, Sree Balaji Dental College and Hospital, Pallikaranai, Chennai-600 100, India.
³ Department of Biochemistry, Allied Health science, Dr. M.G.R Educational and Research Institute, Chennai India.
⁴ Department of Oral and Maxillofacial Pathology, Ragas Dental College and Hospitals, Chennai, India.
⁵ Multi Disciplinary Research Unit, Madurai Medical College, TamilNadu, India.
⁶ State Key Laboratory of Bio-based Materials and Green Papermaking, College of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Science, Jinan 250353, China.
⁷ Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.

PMID: 36518134
PMCID: PMC9722410
DOI: 10.6026/97320630018269

Abstract

We report the molecular docking analysis of four analogues of metformin [1-Carbamimidoyl-1,2-dimethylguanidine hydrochloride, Metformin hydrochloride, N1,N1-Dimethyl-N5-methylbiguanide hydrochloride, and N1,N1,N5,N5-Tetrakis (methyl-biguanide hydrochloride] with GSK3.

Keywords: Diabetes mellitus; GSK-3β; Metformin analogues; Molecular docking studies.

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Conflict of interest statement

None declared

References

1. Tee ES, Yap RWK. Eur J Clin Nutr. . 2017;7:844. - PubMed
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Molecular docking analysis of metformin analogues with GSK-3β

Affiliations

Molecular docking analysis of metformin analogues with GSK-3β

Authors

Affiliations

Abstract

Conflict of interest statement

References

LinkOut - more resources

Full Text Sources