Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct 12:9:1901-1905.
doi: 10.1016/j.toxrep.2022.10.008. eCollection 2022.

Mitigating properties of vitamin E and olive oil on the teratomorphogenic impacts of lambda-cyhalothrin in developing chick embryos

Kashifa Sadaf  1 , Khawaja Raees Ahmad  1 , Syeda Nadia Ahmad  2 , Urooj Kanwal  1 , Sadia Suleman  1 , Zainab Aslam  1 , Iram Inayat  1 , Saira Siddique  1 , Muhammad Ali Kanwal  1
Affiliations

Mitigating properties of vitamin E and olive oil on the teratomorphogenic impacts of lambda-cyhalothrin in developing chick embryos

Kashifa Sadaf et al. Toxicol Rep. .

Abstract

Embryonic toxicity of lambda-cyhalothrin (LCH) and the mitigating properties of extra virgin olive oil (EVO) and vitamin E were investigated in golden black variety of chick embryos. Fifty fertilized eggs distributed in 5 groups received their respective group treatments at zero days of incubation were recovered after 14 days of incubation and fixed in fixative for 48 h for further studies. Results showed that treatment with LCH caused embryonic death, growth retardation and developmental abnormalities such as limbic developments, reduced muscular growth, and embryonic cataract. Post treatment with vitamin E and EVO alone significantly improved all these developmental defects. Morphometric readings also showed that embryos treated with combined dose of vitamin E and EVO had more resemblance towards the control group embryo. These findings suggested that the use of vitamin E and EVO together during pregnancy have the potential to curtail these accidental, environmental and work place exposures of LCH.

Keywords: Gallus domesticus; Lambda cyhalothrin; Morphological abnormalities; Olive oil; Teratology; Vitamin E.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
A: Control (C), B: LCH, C: LCHO, D: LCHE, E: LCHOE, a: Normal Embryonic Eye formation with eye lids, a1: Embryonic Cataract and wide Open Eye, a2: Rudimentary Eye without eyelids, b: Normal Beak, b1: Enlarged Lower Beak, b2: Reduced Lower Beak & Anathia, c: External Auditory Meatus, d: Normal Neck, d1: Skewed Neck, e: Normal Fore-limbs, e1: Fore-limb Meromelia, f: Normal Hind-limbs, f1: Small Hind-limb with Torted Shank, g: Normal Hind-limb Digits, g1: Reduced Hind-limbs or Amelia, g2: Phocomelia, h: Proper Down Development, h1: No Down Development, i: Hemorragia, i1: Multiple Hemorrhagic Spots, j: Suspected Anterior Neuropore Opening, k: Rafe of Neural Crest & feather growth alongside the rafe (Spina bifida), m: Muscular Dystrophy.
See this image and copyright information in PMC

References

    1. Abdel-Tawwab M., El-Saadawy H.A., El-Belbasi H.I., Abd El-Hameed S.A., Attia A.A. Dietary spirulina (Arthrospira platenesis) mitigated the adverse effects of imidacloprid insecticide on the growth performance, haemato-biochemical, antioxidant, and immune responses of Nile tilapia. Comp. Biochem. Physiol. Part C: Toxicol. Pharm. 2021;247 doi: 10.1016/j.cbpc.2021.109067. - DOI - PubMed
    1. Abdul-Ghani M., Naser A. Determination of central nervous effect and antidotal effect against chlorpyrifos toxicity of alpha-lipoic acid through pharmacological and toxicological challenges. SVU-Int. J. Vet. Sci. 2022;5(2):23–30. doi: 10.21608/svu.2022.125628.1181. - DOI
    1. Ahmad K.R., Shehry K., Raees K., Kanwal M.A., Abbas T., Ullah A. Adverse effects of cypermethrin on the chick (Gallus domesticus) development are reversed by co-treatment with vitamin E and olive oil. Pak. Vet. J. 2018;38(1) doi: 10.29261/pakvetj/2018.009. - DOI
    1. Al Malahi N.M., Al Jumaily M.M., Al-shaibani Elham A.S., Alajmi R.A., Alkhuriji A.F., Al-Tamimi J., Alhimaidi A.R. Ameliorative effect of l-carnitine on lambda-cyhalothrin-induced anatomical and reproductive aberrations in albino mice. Saudi J. Biol. Sci. 2022;29(9) doi: 10.1016/j.sjbs.2022.103373. - DOI - PMC - PubMed
    1. Al-Amoudi W.M. Toxic effects of Lambda-cyhalothrin, on the rat thyroid: involvement of oxidative stress and ameliorative effect of ginger extract. Toxicol. Rep. 2018;5:728–736. doi: 10.1016/j.toxrep.2018.06.005. - DOI - PMC - PubMed

LinkOut - more resources