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. 2023 Jul;315(5):1249-1255.
doi: 10.1007/s00403-022-02511-3. Epub 2022 Dec 15.

Fluid Platelet-Rich Fibrin (PRF) Versus Platelet-Rich Plasma (PRP) in the Treatment of Atrophic Acne Scars: A Comparative Study

Nagwa Ali Fahmy Diab  1 , Al-Shimaa M Ibrahim  2 , Aya Mohamed Abdallah  1
Affiliations

Fluid Platelet-Rich Fibrin (PRF) Versus Platelet-Rich Plasma (PRP) in the Treatment of Atrophic Acne Scars: A Comparative Study

Nagwa Ali Fahmy Diab et al. Arch Dermatol Res. 2023 Jul.

Abstract

Platelet-rich fibrin (PRF), a second-generation platelet concentrate, was developed for the purpose of overcoming the limitations of Platelet-rich plasma (PRP). PRF can produce a higher cumulative release of growth factors than PRP. Also, this release is slow and prolonged, making it ideal for tissue regeneration and growth stimulation. This study was conducted to evaluate the efficacy of fluid PRF either alone or combined with needling versus PRP in the treatment of atrophic acne scars. A comparative study including 30 patients with atrophic acne scars who were divided into two equal groups. Group I included 15 patients in which the left side of the face was treated with intradermal injection of PRP while the right side was treated with combined needling with PRP. Group II included15 patients in which the left side of the face was treated with intradermal injection of fluid PRF while the right side was treated with combined needling with fluid PRF. All patients received four sessions with 3 weeks interval. The acne scars significantly improved in both sides of face in both groups. According to quartile grading scale and patient satisfaction; the therapeutic response was significantly higher in PRF group than PRP either alone or combined with needling. The combination with needling increases efficacy of PRF and PRP. Fluid PRF is highly effective, safe and simple procedure that can be used instead of PRP in the treatment of acne scars.

Keywords: PRF; Scar; Wound.

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Conflict of interest statement

The authors declare no competing interests.

None Declared.

Figures

Fig. 1
Fig. 1
30 years old male patient had atrophic acne scar showed excellent improvement after treatment with PRF. Right side treated by combined fluid PRF with needling (a, before treatment), (b, after treatment). Left side of face treated by intradermal injection of PRF only (c, before treatment) (d, after treatment)
Fig. 2
Fig. 2
22 years old female patient had atrophic acne scar showed excellent improvement after treatment with PRF. Right side treated by combined fluid PRF with needling (a, before treatment), (b, after treatment). Left side of face treated by intradermal injection of PRF only (c, before treatment) (d, after treatment)
Fig. 3
Fig. 3
25 years old female patient had atrophic acne scar showed good improvement after treatment with PRP. Right side treated by combined PRP with needling (a, before treatment), (b, after treatment). Left side of face treated by intradermal injection of PRP only (c, before treatment) (d, after treatment)
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