Dexmedetomidine and Propofol Sedation in Critically Ill Patients: How Much Is Too Much?
- PMID: 36520988
- PMCID: PMC10111991
- DOI: 10.1164/rccm.202210-1931ED
Dexmedetomidine and Propofol Sedation in Critically Ill Patients: How Much Is Too Much?
Comment on
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Dexmedetomidine and Propofol Sedation in Critically Ill Patients and Dose-associated 90-Day Mortality: A Secondary Cohort Analysis of a Randomized Controlled Trial (SPICE III).Am J Respir Crit Care Med. 2023 Apr 1;207(7):876-886. doi: 10.1164/rccm.202206-1208OC. Am J Respir Crit Care Med. 2023. PMID: 36215171 Clinical Trial.
References
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- Shehabi Y, Howe BD, Bellomo R, Arabi YM, Bailey M, Bass FE, et al. ANZICS Clinical Trials Group and the SPICE III Investigators Early sedation with dexmedetomidine in critically ill patients. N Engl J Med . 2019;380:2506–2517. - PubMed
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- Shehabi Y, Serpa Neto A, Bellomo R, Howe BD, Arabi YM, Bailey M, et al. SPICE III study investigators Dexmedetomidine and propofol sedation in critically ill patients and dose associated 90-day mortality: a secondary cohort analysis of a randomized controlled trial (SPICE-III) Am J Respir Crit Care Med 2022;2023:876–886. - PubMed
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- Amato MB, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, et al. Driving pressure and survival in the acute respiratory distress syndrome. N Engl J Med . 2015;372:747–755. - PubMed
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- Shehabi Y, Bellomo R, Reade MC, Bailey M, Bass F, Howe B, et al. Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators ANZICS Clinical Trials Group. Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. Am J Respir Crit Care Med . 2012;186:724–731. - PubMed
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