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Editorial
. 2023 Mar 9;46(3):zsac312.
doi: 10.1093/sleep/zsac312.

Overcoming the underdiagnosis of obstructive sleep apnea to empower genetic association analyses

Tamar Sofer  1   2   3
Affiliations
Editorial

Overcoming the underdiagnosis of obstructive sleep apnea to empower genetic association analyses

Tamar Sofer. Sleep. .
No abstract available

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Figures

Figure 1.
Figure 1.
True OSA status versus observed OSA status. Tabulation of the observed OSA status against the true, underlying OSA in a given study. The number of individuals in the study is decomposed into individuals in each of the table cells. The marginal, dark gray, cells sum the individuals in the rows and in the columns. In health records, typically we expect that the number of individuals who in truth do not have OSA yet are observed as having OSA is near zero.
Figure 2.
Figure 2.
Directed acyclic graph connecting OSA, excessive day time sleepiness, and a genetic variant. The directed acyclic graph presents a potential mediation relationship between a genetic variant, OSA, and excessive daytime sleepiness (EDS). Assuming that the effect of g on EDS is only mediate through OSA, given appropriate methodology one can use the estimated association of g  with EDS ORgedsand the estimated association of OSA with EDS ORosaeds to estimate ORgosa.
See this image and copyright information in PMC

Comment on

References

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