Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb:127:124-128.
doi: 10.1016/j.ijid.2022.12.011. Epub 2022 Dec 13.

Hospital at home treatment with remdesivir for patients with COVID-19: real-life experience

Irene Pereta  1 , Alma Morancho  2 , Néstor López  2 , Begoña Ibáñez  1 , Cristina Salas  3 , Laura Moreno  1 , Eva Castells  1 , Ariadna Barta  3 , Marta Cubedo  4 , Emmanuel Coloma  5 , Celia Cardozo  5 , Nicole García-Pouton  5 , Ainoa Ugarte  6 , Andrea Rivero  7 , Marta Bodro  5 , Verónica Rico  5 , Laura García  1 , Jordi Altés  1 , Nuria Seijas  1 , David Nicolás  8
Affiliations

Hospital at home treatment with remdesivir for patients with COVID-19: real-life experience

Irene Pereta et al. Int J Infect Dis. 2023 Feb.

Abstract

Objectives: Access and appropriateness of therapeutics for COVID-19 vary because of access or regulatory barriers, the severity of the disease, and for some therapies, the stage of the pandemic and circulating variants. Remdesivir has shown benefits in clinical recovery and is the treatment of choice for selected patients, both hospitalized and nonhospitalized, in main international guidelines. The use of remdesivir in alternatives to conventional hospitalization such as hospital at home (HaH) units remains incompletely explored. In this study, we aim to describe the real-life experience of outpatient remdesivir infusion for COVID-19 in a HaH unit.

Methods: We selected all the consecutive patients receiving remdesivir from a prospective cohort of 507 COVID-19 patients admitted at a HaH unit. Admission criteria included COVID-19 with a fraction of inspired oxygen requirement under 0.35 and respiratory rate under 22 rpm. Patients were daily assessed in person by a nurse and a physician.

Results: A total of 236 patients admitted at the HaH unit received remdesivir, 172 of whom were treated at home. Only 2% presented any adverse event related to the infusion, all of them mild. HaH saved 1416 day-beds, with only 5% of the patients requiring transfer back to the hospital.

Conclusion: Remdesivir infusion in HaH units seems to be a safe and efficient alternative to conventional hospitalization for treating patients with nonsevere COVID-19.

Keywords: COVID-19; Hospital at home; Management; Outcomes; Outpatient; Remdesivir.

PubMed Disclaimer

Conflict of interest statement

Declarations of competing interest The authors have no competing interests to declare.

Figures

Fig. 1
Fig. 1
Alluvial graphic showing patient allocation at each step of the process. HaH, Hospital-at-Home.
See this image and copyright information in PMC

References

    1. Nicolás D, Coloma E, Pericàs JM. Alternatives to conventional hospitalisation that enhance health systems’ capacity to treat COVID-19. Lancet Infect Dis. 2021;21:591–593. doi: 10.1016/S1473-3099(21)00093-1. - DOI - PMC - PubMed
    1. Heller DJ, Ornstein KA, DeCherrie LV, et al. Adapting a hospital-at-home care model to respond to New York City's COVID-19 crisis. J Am Geriatr Soc. 2020;68:1915–1916. doi: 10.1111/jgs.16725. - DOI - PMC - PubMed
    1. Nogués X, Sánchez-Martinez F, Castells X, et al. Hospital-at-home expands hospital capacity during COVID-19 pandemic. J Am Med Dir Assoc. 2021;22:939–942. doi: 10.1016/j.jamda.2021.01.077. - DOI - PMC - PubMed
    1. Huynh DN, Millan A, Quijada E, et al. Description and early results of the Kaiser Permanente Southern California COVID-19 home monitoring program. Perm J. 2021;25 20.281. - PMC - PubMed
    1. Nicolás D, Camós-Carreras A, Spencer F, et al. A prospective cohort of SARS-CoV-2-Infected health care workers: clinical characteristics, outcomes, and follow-up strategy. Open Forum Infect Dis. 2021;8:ofaa592. doi: 10.1093/ofid/ofaa592. - DOI - PMC - PubMed