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. 2022 Dec 16:27:e938114.
doi: 10.12659/AOT.938114.

Acute Pancreatitis in Patients After Liver Transplantation

Alzbeta Hujova  1 , Peter Macinga  1 , Jana Jarosova  1 , Jiri Fronek  2 , Pavel Taimr  1 , Julius Spicak  1 , Tomas Hucl  1
Affiliations

Acute Pancreatitis in Patients After Liver Transplantation

Alzbeta Hujova et al. Ann Transplant. .

Abstract

BACKGROUND Acute pancreatitis (AP) is a relatively rare but serious complication that can occur after organ transplantation. MATERIAL AND METHODS The aim of this study was to evaluate the incidence, potential risk factors, and course of AP in patients following liver transplantation at a single large-volume transplant center. RESULTS Out of a total of 1850 transplanted patients, 49 (2.8%) were diagnosed with AP. Of this group, 37 (75.5%) had a mild form of AP and 12 (24.5%) had a severe form of AP. The mortality rate was 10% overall and 42% in the group of patients with severe AP. An early form of AP (<30 days from transplantation) occurred in 13 patients (26.5%), most of whom presented with severe AP (10 patients, 76.9%); 4 patients died (40%). A late form of AP was diagnosed in 36 patients (73.5%), most of whom had mild AP (34 patients, 94.4%); 1 of 2 patients with severe AP died. The most common AP etiologies were post-ERCP (38.8%), idiopathic (34.7%), and postoperative (18.4%). Chronic HBV infection was a risk factor for development of AP (P=0.01). CONCLUSIONS AP in liver transplant recipients was more frequent and more severe than in the general population. This unfavorable course was associated with the occurrence of AP in the early post-transplant period. Liver transplantation due to complications of HBV infection was a risk factor for the development of AP.

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Conflict of interest statement

Conflict of interest: None declared

Figures

Figure 1
Figure 1
Number of patients with AP after liver transplantation based on its severity, created in Numbers (version 4.1.1, 4338).
Figure 2
Figure 2
Number of patients with AP after liver transplantation based on the time from transplantation, created in Numbers (version 4.1.1, 4338).
Figure 3
Figure 3
Mortality rate of acute pancreatitis after liver transplantation depending on the severity and time from the transplantation, created in Numbers (version 4.1.1, 4338).
See this image and copyright information in PMC

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