Review

. 2023 Dec;48(12):3585-3600.

doi: 10.1007/s00261-022-03757-1. Epub 2022 Dec 16.

PET/MRI imaging in neuroendocrine neoplasm

Mayur K Virarkar¹, Matthew Montanarella¹, Malak Itani², Luis Calimano-Ramirez³, Dheeraj Gopireddy¹, Priya Bhosale⁴

Affiliations

¹ Department of Radiology, University of Florida College of Medicine, Jacksonville, FL, 32209, USA.
² Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, 510 S Kings Highway Blvd, Campus Box 8131, St Louis, MO, 63110, USA.
³ Department of Radiology, University of Florida College of Medicine, Jacksonville, FL, 32209, USA. luis.calimanoramirez@jax.ufl.edu.
⁴ Division of Diagnostic Imaging, Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

PMID: 36525051
DOI: 10.1007/s00261-022-03757-1

Review

PET/MRI imaging in neuroendocrine neoplasm

Mayur K Virarkar et al. Abdom Radiol (NY). 2023 Dec.

. 2023 Dec;48(12):3585-3600.

doi: 10.1007/s00261-022-03757-1. Epub 2022 Dec 16.

Authors

Mayur K Virarkar¹, Matthew Montanarella¹, Malak Itani², Luis Calimano-Ramirez³, Dheeraj Gopireddy¹, Priya Bhosale⁴

Affiliations

¹ Department of Radiology, University of Florida College of Medicine, Jacksonville, FL, 32209, USA.
² Mallinckrodt Institute of Radiology, Washington University in St. Louis School of Medicine, 510 S Kings Highway Blvd, Campus Box 8131, St Louis, MO, 63110, USA.
³ Department of Radiology, University of Florida College of Medicine, Jacksonville, FL, 32209, USA. luis.calimanoramirez@jax.ufl.edu.
⁴ Division of Diagnostic Imaging, Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

PMID: 36525051
DOI: 10.1007/s00261-022-03757-1

Abstract

Molecular imaging plays a vital role in the management of neuroendocrine neoplasms (NENs). Somatostatin receptor (SSTR) PET is critical for evaluating NENs, ascertaining peptide receptor radionuclide therapy (PRRT) eligibility, and treatment response. SSTR-PET/MRI can provide a one-stop-shop multiparametric evaluation of NENs. The acquisition of complementary imaging information in PET/MRI has distinct advantages over PET/CT and MR imaging acquisitions. The purpose of this manuscript is to provide a comprehensive overview of PET/MRI and a current review of recent PET/MRI advances in the diagnosis, staging, treatment, and surveillance of NENs.

Keywords: Neuroendocrine neoplasm; PET/CT; PET/MRI; PPRT; SSTR.

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References

1. Ambrosini, V., et al., Consensus on molecular imaging and theranostics in neuroendocrine neoplasms. Eur J Cancer, 2021. 146: p. 56–73. - PubMed - PMC - DOI
1. Taal, B.G. and O. Visser, Epidemiology of neuroendocrine tumours. Neuroendocrinology, 2004. 80 Suppl 1: p. 3–7. - PubMed - DOI
1. Oronsky, B., et al., Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas. Neoplasia, 2017. 19(12): p. 991–1002. - PubMed - PMC - DOI
1. Rajamohan, N., et al., PET/CT and PET/MRI in neuroendocrine neoplasms. Abdom Radiol (NY), 2022.
1. Crona, J. and B. Skogseid, GEP- NETS UPDATE: Genetics of neuroendocrine tumors. Eur J Endocrinol, 2016. 174(6): p. R275–90. - PubMed - DOI

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PET/MRI imaging in neuroendocrine neoplasm

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PET/MRI imaging in neuroendocrine neoplasm

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