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Comment
. 2023 Jan 3;122(1):1-3.
doi: 10.1016/j.bpj.2022.12.006. Epub 2022 Dec 6.

Transcription-translation coupling: Traveling a road under construction

Stefan Klumpp  1
Affiliations
Comment

Transcription-translation coupling: Traveling a road under construction

Stefan Klumpp. Biophys J. .
No abstract available

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Figures

Figure 1
Figure 1
Cotranscriptional translation: A ribosome follows an RNAP on the mRNA transcript the RNAP generates. Do the two molecular machines “dock” together to form a supercomplex, the expressome, when the ribosome catches up? If yes, is their coupling direct or mediated by Nus factors? Is the coupling tight or transient and stochastic? To see this figure in color, go online.
See this image and copyright information in PMC

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References

    1. Vogel U., Jensen K.F. The RNA chain elongation rate in Escherichia coli depends on the growth rate. J. Bacteriol. 1994;176:2807–2813. - PMC - PubMed
    1. Proshkin S., Rahmouni A.R., et al. Nudler E. Cooperation between translating ribosomes and RNA polymerase in transcription elongation. Science. 2010;328:504–508. doi: 10.1126/science.1184939. - DOI - PMC - PubMed
    1. Kohler R., Mooney R.A., et al. Cramer P. Architecture of a transcribing-translating expressome. Science. 2017;356:194–197. doi: 10.1126/science.aal3059. - DOI - PMC - PubMed
    1. O'Reilly F.J., Xue L., et al. Rappsilber J. In-cell architecture of an actively transcribing-translating expressome. Science. 2020;369:554–557. doi: 10.1126/science.abb3758. - DOI - PMC - PubMed
    1. Burmann B.M., Schweimer K., et al. Rösch P. A NusE:NusG complex links transcription and translation. Science. 2010;328:501–504. doi: 10.1126/science.1184953. - DOI - PubMed

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