Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987;95(5):366-74.
doi: 10.1007/BF00293184.

Three-dimensional reconstruction of a human metaphase chromosome from electron micrographs

G Harauz  1 , L Borland, G F Bahr, E Zeitler, M van Heel
Affiliations

Three-dimensional reconstruction of a human metaphase chromosome from electron micrographs

G Harauz et al. Chromosoma. 1987.

Abstract

A complete human metaphase chromosome has been reconstructed from a series of electron microscopical projections obtained by tilting the specimen stage at 3 degree intervals from -60 to +60 degrees. The reconstructed structure is about 3.0 microns long, 1.6 micron wide, and 0.8 micron thick. The mass distribution was fairly homogeneous within the chromatids and neither a hollow nor a dense core was observed. The distribution and course of fibers observed are most consistent with a looping model of chromosome structure.

PubMed Disclaimer

References

    1. Science. 1971 Mar 12;171(3975):1024-6 - PubMed
    1. Cold Spring Harb Symp Quant Biol. 1978;42 Pt 1:331-50 - PubMed
    1. Science. 1983 Apr 29;220(4596):498-500 - PubMed
    1. Chromosoma. 1980;76(1):23-33 - PubMed
    1. Chromosoma. 1986;93(6):511-4 - PubMed

Publication types