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Review
. 2022 Dec 17;26(1):391.
doi: 10.1186/s13054-022-04273-w.

The pathogenesis and therapeutic strategies of heat stroke-induced liver injury

Fuquan Wang  1   2 , Yan Zhang  1   2 , Jianhua Li  3 , Haifa Xia  1   2 , Dingyu Zhang  4   5   6 , Shanglong Yao  7   8
Affiliations
Review

The pathogenesis and therapeutic strategies of heat stroke-induced liver injury

Fuquan Wang et al. Crit Care. .

Abstract

Heat stroke (HS) is a life-threatening systemic disease characterized by an elevated core body temperature of more than 40 ℃ and subsequent multiple organ dysfunction syndrome. With the growing frequency of global heatwaves, the incidence rate of HS has increased significantly, which has caused a huge burden on people's lives and health. Liver injury is a well-documented complication of HS and usually constitutes the direct cause of patient death. In recent years, a lot of research has been carried out on the pathogenesis and treatment strategies of HS-induced liver injury. In this review, we summarized the important pathogenesis of HS-induced liver injury that has been confirmed so far. In addition to the comprehensive effect of systemic factors such as heat cytotoxicity, coagulopathy, and systemic inflammatory response syndrome, excessive hepatocyte cell pyroptosis, dysfunction of Kupffer cells, abnormal expression of heat shock protein expression, and other factors are also involved in the pathogenesis of HS-induced liver injury. Furthermore, we have also established the current therapeutic strategies for HS-induced liver injury. Our study is of great significance in promoting the understanding of the pathogenesis and treatment of HS-induced liver injury.

Keywords: Heat stroke; Liver injury; Pathogenesis; Therapeutic strategy.

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Conflict of interest statement

The authors declare no competing financial interests.

Figures

Fig. 1
Fig. 1
The related mechanism of hepatocyte injury during HS-induced liver injury. In addition to direct heat injury, HS can cause liver injury through various mechanisms, including inhibiting the expression of HSP70 of hepatocytes, promoting the production of ROS, promoting the inflammatory response and pyropsis, etc.
Figure2
Figure2
The main treatment strategies for HS-induced liver injury. It mainly focuses on systematic support treatment, including cooling treatment, early oxygen supply, CBP, anticoagulant therapy, and anti-inflammatory treatment. For those with irreversible liver injury, liver transplantation provides a possible choice
See this image and copyright information in PMC

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