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. 2023 Apr;44(4):1281-1288.
doi: 10.1007/s10072-022-06544-4. Epub 2022 Dec 19.

Association between fibrinogen-to-albumin ratio and hemorrhagic transformation after intravenous thrombolysis in ischemic stroke patients

Miaomiao Yang  1 , Lisha Tang  1 , Shijia Bing  1 , Xiangqi Tang  2
Affiliations

Association between fibrinogen-to-albumin ratio and hemorrhagic transformation after intravenous thrombolysis in ischemic stroke patients

Miaomiao Yang et al. Neurol Sci. 2023 Apr.

Abstract

Background and purpose: Hemorrhagic transformation (HT) is the most serious complication of intravenous thrombolysis in ischemic stroke patients. Inflammation plays a critical role in the pathological progression of HT. This study was to explore the relationship between fibrinogen-to-albumin ratio (FAR), a novel systemic inflammation biomarker, and HT after intravenous thrombolysis in patients with ischemic stroke.

Methods: This retrospective study enrolled ischemic stroke patients who underwent intravenous thrombolysis between Jan 2017 to May 2022. The characteristic data of all patients at admission were retrospectively collected. The univariate and multivariate logistic regression analyses were performed to evaluate the correlation between FAR and HT after intravenous thrombolysis. The optimal cut-off value of FAR for predicting HT was determined by the receiver operating characteristic curve.

Results: A total of 363 ischemic stroke patients were enrolled in the present study. Sixty-two patients had HT after intravenous thrombolysis. In multivariate regression analysis, FAR was significantly associated with HT (odds ratio [OR], 1.105; 95% confidential interval [CI], 1.029-1.186, P = 0.006). The receiver operating characteristic curve analysis indicated FAR predicts HT after intravenous thrombolysis with an AUC of 0.613 (95%CI, 0.530-0.695; P = 0.005) and an optimal cut-off value of 0.101. The correlation between FAR and HT after intravenous thrombolysis was still observed when patients were stratified according to FAR levels. A higher FAR level was independently related to the occurrence of HT after adjusting for the potential confounding factors.

Conclusion: Higher FAR level was independently associated with HT after intravenous thrombolysis in patients with ischemic stroke.

Keywords: Fibrinogen-to-albumin ratio; Hemorrhagic transformation; Intravenous thrombolysis; Ischemic stroke; Neuroinflammation.

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References

    1. Phipps MS, Cronin CA (2020) Management of acute ischemic stroke. BMJ (Clinical research ed) 368:l6983. https://doi.org/10.1136/bmj.l6983 - DOI - PubMed
    1. Wu S, Wu B, Liu M, Chen Z, Wang W, Anderson CS et al (2019) Stroke in China: advances and challenges in epidemiology, prevention, and management. The Lancet Neurology 18(4):394–405. https://doi.org/10.1016/s1474-4422(18)30500-3 - DOI - PubMed
    1. Shaheryar ZA, Khan MA, Adnan CS, Zaidi AA, Hänggi D, Muhammad S (2021) Neuroinflammatory triangle presenting novel pharmacological targets for ischemic brain injury. Front Immunol 12:748663. https://doi.org/10.3389/fimmu.2021.748663 - DOI - PubMed - PMC
    1. Yang C, Hawkins KE, Doré S, Candelario-Jalil E (2019) Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. Am J Physiol Cell Physiol 316(2):C135–C153. https://doi.org/10.1152/ajpcell.00136.2018 - DOI - PubMed
    1. Ma G, Pan Z, Kong L, Du G (2021) Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: potential mechanisms, targets, therapeutic drugs and biomarkers. Int Immunopharmacol 90:107216. https://doi.org/10.1016/j.intimp.2020.107216 - DOI - PubMed

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