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Review
. 2023 Jun;71(3):287-313.
doi: 10.1007/s12026-022-09352-2. Epub 2022 Dec 19.

Lipocalin 2-not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials

Sumaira Asaf  1 , Fazeela Maqsood  2 , Javeria Jalil  3 , Zouina Sarfraz  2 , Azza Sarfraz  4   5 , Shabbir Mustafa  6 , Ivan Cherrez Ojeda  7
Affiliations
Review

Lipocalin 2-not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials

Sumaira Asaf et al. Immunol Res. 2023 Jun.

Abstract

Lipocalin 2 (Lcn2), also known as neutrophil gelatinase-associated lipocalin, is an innate immune protein encoded by the LCN2 gene. In this study, we investigated various roles and functions of Lcn2 characterized in a systems-based format and evaluated its therapeutic potentials and clinical relevance for diagnosis and prognosis. An additional systematic presentation was presented for 70 ongoing clinical trials utilizing Lcn2 in the diagnostic and prognostic setting as a key outcome measure. With trials being conducted through December 2030, Lcn2 will become all the more relevant given its associations with diseases as a prognostic biomarker. Data also suggests that it plays a role in pathological conditions. The gaps in our understanding of Lcn2, once filled, may improve the immune mediation of acute and chronic disease.

Keywords: Biomarker; Clinical trials; Innate immunity; Lipocalin 2; Pathophysiology.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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