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Review
. 2022 Nov 30:12:1001693.
doi: 10.3389/fonc.2022.1001693. eCollection 2022.

The roles and clinical applications of interleukins in endometrial carcinoma

Yuqin Zang  1   2 , Huanrong Li  1   2 , Shiqi Liu  1   2 , Ruqian Zhao  1   2 , Kaiwen Zhang  1   2 , Yuqi Zang  3 , Yingmei Wang  1   2 , Fengxia Xue  1   2
Affiliations
Review

The roles and clinical applications of interleukins in endometrial carcinoma

Yuqin Zang et al. Front Oncol. .

Abstract

As a common malignant tumor of the female reproductive system, endometrial carcinoma (EC) seriously endangers women's health with an increasing incidence. The oncogenesis and progression of cancer are closely linked with immune microenvironment, of which interleukins are the important components. In order to illustrate the roles and clinical applications of interleukins in EC, literature of interleukins and EC were reviewed. Based on the present studies, interleukins play crucial roles in the oncogenesis and development of EC via regulating the proliferation, migration, invasion, angiogenesis, apoptosis, pyroptosis and autophagy of EC as well as the immune function against EC. And some of the interleukins seems to have prospective clinical applications in EC, such as evaluating the risk of tumorigenesis, discriminating the malignancy from benign disorders or normal condition, indicating cancer aggressiveness, predicting the prognosis of patients and serving as the novel therapy. However, there is still a long way to go before the clinical applications of interleukins in EC come into reality. Nevertheless, it is certain that the exploration of interleukins will definitely be of great benefit to the screening, diagnosis and treatment of EC in the future.

Keywords: clinical application; endometrial cancer; expression; interleukin; mechanism.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Classifications and structures of the interleukin family.
Figure 2
Figure 2
Roles and mechanisms of interleukins in EC oncogenesis and progression. Interleukin in red color means that it exerts a promoting effect on the process, while interleukin in blue color means that it exerts a suppressing effect on the process.
Figure 3
Figure 3
Clinical applications of interleukins in EC.
See this image and copyright information in PMC

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