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Review
. 2022 Nov 30:13:1035451.
doi: 10.3389/fimmu.2022.1035451. eCollection 2022.

Involvement of caveolin-1 in skin diseases

Naoko Takamura  1 , Yukie Yamaguchi  1
Affiliations
Review

Involvement of caveolin-1 in skin diseases

Naoko Takamura et al. Front Immunol. .

Abstract

The skin is the outermost layer and largest organ in the human body. Since the skin interfaces with the environment, it has a variety of roles, including providing a protective barrier against external factors, regulating body temperature, and retaining water in the body. It is also involved in the immune system, interacting with immune cells residing in the dermis. Caveolin-1 (CAV-1) is essential for caveolae formation and has multiple functions including endocytosis, lipid homeostasis, and signal transduction. CAV-1 is known to interact with a variety of signaling molecules and receptors and may influence cell proliferation and migration. Several skin-related disorders, especially those of the inflammatory or hyperproliferative type such as skin cancers, psoriasis, fibrosis, and wound healing, are reported to be associated with aberrant CAV-1 expression. In this review, we have explored CAV-1 involvement in skin physiology and skin diseases.

Keywords: aging; caveolin-1; fibrosis; psoriasis; skin; skin cancer; skin infection.

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Conflict of interest statement

YY declares research grants, and/or consulting fees, and/or speaker’s fees from AbbVie, Amgen, Astellas, Boehringer Ingelheim, Eisai, Eli Lilly, Janssen, Kyowa Kirin, LEO Pharma, Maruho, Mitsubishi Tanabe, Novartis, Sun Pharmaceutical Industries, Taiho Pharmaceutical, Torii Pharmaceutical, and UCB Japan. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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