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. 2022 Dec 2:13:1017444.
doi: 10.3389/fimmu.2022.1017444. eCollection 2022.

Bidirectional two-sample Mendelian randomization study of causality between rheumatoid arthritis and myocardial infarction

Hao-Yang Guo  1 , Wei Wang  1 , Hui Peng  2 , Hui Yuan  1
Affiliations

Bidirectional two-sample Mendelian randomization study of causality between rheumatoid arthritis and myocardial infarction

Hao-Yang Guo et al. Front Immunol. .

Abstract

Background: Epidemiological evidence suggests an association between rheumatoid arthritis (RA) and myocardial infarction (MI). However, causality remains uncertain. Therefore, this study aimed to explore the causal association between RA and MI.

Methods: Using publicly available genome-wide association study summary datasets, bidirectional two-sample Mendelian randomization (TSMR) was performed using inverse-variance weighted (IVW), weighted median, MR-Egger regression, simple mode, and weighted mode methods.

Results: The MR results for the causal effect of RA on MI (IVW, odds ratio [OR] = 1.041, 95% confidence interval [CI]: 1.007-1.076, P = 0.017; weighted median, OR = 1.027, 95% CI: 1.006-1.049, P = 0.012) supported a causal association between genetic susceptibility to RA and an increased risk of MI. MR results for the causal effect of MI on RA (IVW, OR = 1.012, 95% CI: 0.807-1.268, P = 0.921; weighted median, OR = 1.069, 95% CI: 0.855-1.338, P = 0.556) indicated that there was no causal association between genetic susceptibility to MI and an increased risk of RA.

Conclusion: Bidirectional TSMR analysis supports a causal association between genetic susceptibility to RA and an increased risk of MI but does not support a causal association between genetic susceptibility to MI and an increased risk of RA.

Keywords: bidirectional; causal association; myocardial infarction; rheumatoid arthritis; two-sample Mendelian randomization study.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Forest plot (A), scatter plot (B), sensitivity analysis (C), and funnel plot (D) of the effect of RA on MI.
Figure 2
Figure 2
Forest plot (A), scatter plot (B), sensitivity analysis (C), and funnel plot (D) of the effect of MI on RA.
See this image and copyright information in PMC

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