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Comment
. 2022 Nov 21:11:35.
doi: 10.12703/r-01-0000019. eCollection 2022.

A genetic roadmap to the response to genotoxic agents in human cells

Alberto Ciccia  1 , Roger A Greenberg  2 , Susan P Lees-Miller  3 , Andre Nussenzweig  4
Affiliations
Comment

A genetic roadmap to the response to genotoxic agents in human cells

Alberto Ciccia et al. Fac Rev. .

Abstract

To maintain genome fidelity and prevent diseases such as cancer, our cells must constantly detect, and efficiently and precisely repair, DNA damage. Paradoxically, DNA-damaging agents in the form of radiation and chemotherapy are also used to treat cancer. Olivieri et al. used a CRISPR-based screen to identify genes that, when disrupted, lead to sensitivity or resistance to 27 different DNA-damaging agents used in the lab and/or in the clinic to treat cancer patients1. Their results reveal multiple new genes and connections that regulate these critical DNA damage repair pathways, with implications for basic and clinical research as well as cancer therapy.

Keywords: CRISPR; DNA damage; DNA repair; DNA-damaging agents.

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Conflict of interest statement

R.A.G is a co-founder and scientific advisory board member of RADD Pharmaceuticals. The remaining authors declare that they have no competing interests.

Comment on

  • A Genetic Map of the Response to DNA Damage in Human Cells.
    Olivieri M, Cho T, Álvarez-Quilón A, Li K, Schellenberg MJ, Zimmermann M, Hustedt N, Rossi SE, Adam S, Melo H, Heijink AM, Sastre-Moreno G, Moatti N, Szilard RK, McEwan A, Ling AK, Serrano-Benitez A, Ubhi T, Feng S, Pawling J, Delgado-Sainz I, Ferguson MW, Dennis JW, Brown GW, Cortés-Ledesma F, Williams RS, Martin A, Xu D, Durocher D. Olivieri M, et al. Cell. 2020 Jul 23;182(2):481-496.e21. doi: 10.1016/j.cell.2020.05.040. Epub 2020 Jul 9. Cell. 2020. PMID: 32649862 Free PMC article.

References

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