Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec 19;39(4):e2022041.
doi: 10.36141/svdld.v39i4.11350.

A case of hepatic and bone marrow sarcoidosis with progressive renal failure: diagnostic and therapeutic challenges

Pierluigi Brugnaro  1 , Francesca Cattelan  2 , Erika Morelli  3 , Andrea Petrucci  4 , Alessandro Marocco  5 , Sandro Panese  6 , Pietro Maria Donisi  7 , Giovanni Capitanio  8 , Mauro Tollot  9
Affiliations

A case of hepatic and bone marrow sarcoidosis with progressive renal failure: diagnostic and therapeutic challenges

Pierluigi Brugnaro et al. Sarcoidosis Vasc Diffuse Lung Dis. .

Abstract

Sarcoidosis is a systemic granulomatous disease, sometimes characterized by an extrapulmonary localization in 30 - 50% of cases. We describe a 60-year-old Italian man with an unexplained history of fatigue, ascitis and progressive renal function impairment. Diagnosis of hepatic and bone marrow sarcoidosis was established by histology, and fast improvement of renal function was obtained after starting corticosteroid therapy. Atypical presentation and simultaneous involvement of liver, bone marrow and kidneys make diagnosis of extrapulmonary sarcoidosis still a diagnostic challenge. Delayed diagnosis could lead to serious organ damage like a progressive severe kidney failure.

PubMed Disclaimer

Conflict of interest statement

Each author declares that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangement etc.) that might pose a conflict of interest in connection with the submitted article.

Figures

Figure 1.
Figure 1.
Figure 2.
Figure 2.
Figure 3.
Figure 3.
See this image and copyright information in PMC

References

    1. Valeyre D, Prasse A, Nunes H, Uzunan Y, Brillet P-Y, Müller-Quernheim Y. Sarcoidosis. Lancet. 2014;383:1155–1167. - PubMed
    1. Tana C, Tana M, Mezzetti A, Schiavone C. Sarcoidosis: old certainties and new perspectives. It J Med. 2012;6:186–194.
    1. Baughman RP, Teirstein AS, Judson MA, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164:1885–1889. - PubMed
    1. Levey AS, Eckardt KU, Tsukamoto Y, et al. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO) Kidney Int. 2005;67:2089–2100. - PubMed
    1. Morgenthau AS, Teirstein AS. Sarcoidosis of the upper and lower airways. Expert Rev Respir Med. 2011;5:823–33. - PubMed

LinkOut - more resources