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. 2023 Jan 24;67(1):e0220121.
doi: 10.1128/aac.02201-21. Epub 2022 Dec 19.

Omadacycline Pharmacokinetics: Influence of Mortality Risk Score among Patients with Community-Acquired Bacterial Pneumonia

M Trang  1 , J P Hammel  1 , E A Lakota  1 , M C Safir  1 , S M Bhavnani  1 , L Friedrich  2 , J N Steenbergen  2 , P C McGovern  2 , E Tzanis  2 , C M Rubino  1
Affiliations

Omadacycline Pharmacokinetics: Influence of Mortality Risk Score among Patients with Community-Acquired Bacterial Pneumonia

M Trang et al. Antimicrob Agents Chemother. .
No abstract available

Keywords: community-acquired bacterial pneumonia; omadacycline; pharmacokinetics.

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Conflict of interest statement

The authors declare a conflict of interest. M.T., M.C.S., J.P.H., S.M.B., and C.M.R. are employees of the Institute for Clinical Pharmacodynamics, Inc., which has received research support from Paratek Pharmaceuticals, Inc. E.A.L. was an employee of ICPD at the time the analyses were performed and is now and employee of Vertex Pharmaceuticals, Inc. L.F. was an employee of Paratek Pharmaceuticals, Inc., at the time the analyses were performed and is now an employee of AN2 Therapeutics. J.N.S. was an employee of Paratek Pharmaceuticals, Inc., at the time the analyses were performed and is now an employee of Scientific and Medical Affairs Consulting, LLC. P.C.M. was an employee of Paratek Pharmaceuticals, Inc., at the time the analyses were performed and is now an employee of VenatoRx, Inc., and E.T. was an employee of Paratek Pharmaceuticals, Inc., at the time the analyses were performed and is now an employee of Neuraptive Therapeutics, Inc.

Figures

FIG 1
FIG 1
Box-and-whisker plot showing the distribution of day 1 omadacycline total-drug plasma AUC0–24, stratified by sex and each PORT risk class and CURB-65 score. The upper and lower edges of each box represent the 25th and 75th percentiles of the distribution of total-drug plasma AUC0–24, respectively. The line within each box represents the median total-drug plasma AUC0–24 value. The upper and lower whiskers extend to the furthest observed values within 1.5 × IQR of the respective box edges (where IQR is defined as the difference between the 25th and 75th percentiles).
See this image and copyright information in PMC

References

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