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Review
. 2023 Mar;38(3):378-385.
doi: 10.1111/jgh.16087. Epub 2022 Dec 29.

Mechanism of ASK1 involvement in liver diseases and related potential therapeutic targets: A critical pathway molecule worth investigating

Qi Chen  1 , Jiayu Guo  1 , Tao Qiu  1 , Jiangqiao Zhou  1
Affiliations
Review

Mechanism of ASK1 involvement in liver diseases and related potential therapeutic targets: A critical pathway molecule worth investigating

Qi Chen et al. J Gastroenterol Hepatol. 2023 Mar.

Abstract

Since the discovery of apoptosis signal-regulated kinase 1 (ASK1), the signal transduction mechanism and pathophysiological process involved in its regulation have been continuously revealed. Many previous studies have identified that ASK1 is involved and plays a critical role in the development of diseases affecting the nervous, cardiac, renal, and other systems. As a mitogen-activated protein kinase (MAPK) kinase kinase, ASK1 mediates apoptosis, necrosis, inflammation, and other pathological processes by activating its downstream c-Jun N-terminal kinase (JNK)/p38 MAPK. Owing to the important role of ASK1, an increasing number of studies in recent years have focused on its status in liver-related diseases. In this paper, we review the mechanisms and targets of ASK1 in liver-related diseases to emphasize its important role in the development of liver disease.

Keywords: apoptosis signal-regulated kinase 1; liver diseases; mitogen-activated protein kinase.

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References

    1. Soga M, Matsuzawa A, Ichijo H. Oxidative stress-induced diseases via the ASK1 signaling pathway. Int. J. Cell Biol. 2012; 2012: 439587.
    1. Ogier JM, Nayagam BA, Lockhart PJ. ASK1 inhibition: a therapeutic strategy with multi-system benefits. J. Mol. Med. (Berl) 2020; 98: 335-348.
    1. Bunkoczi G, Salah E, Filippakopoulos P et al. Structural and functional characterization of the human protein kinase ASK1. Structure 2007; 15: 1215-1226.
    1. Cohen JJ. Apoptosis. Immunol. Today 1993; 14: 126-130.
    1. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972; 62: 239-257.

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