First-line lorlatinib for advanced ALK-positive non-small-cell lung cancer
- PMID: 36535299
- DOI: 10.1016/S2213-2600(22)00488-X
First-line lorlatinib for advanced ALK-positive non-small-cell lung cancer
Conflict of interest statement
JJL reports consulting fees from Genentech, C4 Therapeutics, Blueprint Medicines, Nuvalent, Bayer, Elevation Oncology, Novartis, Mirati Therapeutics, Regeneron, Turning Point Therapeutics, and Pfizer (<US$5000 per year); institutional research funding from Hengrui Therapeutics, Turning Point Therapeutics, Neon Therapeutics, Relay Therapeutics, Bayer, Elevation Oncology, Roche, Linnaeus Therapeutics, Nuvalent, and Novartis; and continuing medical education funding from OncLive, MedStar Health, MLI PeerView, HMP Education, and Northwell Health. JFG has served as a compensated consultant or received honoraria from Bristol Myers Squibb, Genentech/Roche, Takeda, Loxo/Lilly, Blueprint, Gilead, Moderna, AstraZeneca, Curie Therapeutics, Mirati, Nuvalent, Pfizer, Novartis, Merck, iTeos, Karyopharm, Silverback Therapeutics, and GlydeBio; has received research support from Novartis, Genentech/Roche, and Takeda; and institutional research support from Bristol Myers Squibb, Tesaro, Moderna, Blueprint, Jounce, Array Biopharma, Merck, Adaptimmune, Novartis, and Alexo; and has an immediate family member who is an employee with equity at Ironwood Pharmaceuticals.
Comment on
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Efficacy and safety of first-line lorlatinib versus crizotinib in patients with advanced, ALK-positive non-small-cell lung cancer: updated analysis of data from the phase 3, randomised, open-label CROWN study.Lancet Respir Med. 2023 Apr;11(4):354-366. doi: 10.1016/S2213-2600(22)00437-4. Epub 2022 Dec 16. Lancet Respir Med. 2023. PMID: 36535300 Clinical Trial.
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