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Review
. 2023 Jan 1;36(1):18-23.
doi: 10.1097/01.ASW.0000891856.08360.61.

Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review

Amelia Spinella  1 , Marco de Pinto, Carlo Baraldi, Claudio Galluzzo, Sofia Testoni, Federica Lumetti, Luca Parenti, Simona Guerzoni, Carlo Salvarani, Dilia Giuggioli
Affiliations
Review

Topical Cannabidiol in the Treatment of Digital Ulcers in Patients with Scleroderma: Comparative Analysis and Literature Review

Amelia Spinella et al. Adv Skin Wound Care. .

Abstract

Objective: To explore the effect of topical cannabidiol (CBD) in treating digital ulcers in patients with systemic sclerosis (SSc).

Methods: In total, 45 patients with SSc who had digital ulcers were consecutively enrolled between January 2019 and December 2019. Of the participants, 25 were treated with CBD during surgical debridement and 20 were treated with standard local therapy. A numeric rating scale for pain and Health Assessment Questionnaire Disability Index were administered at the baseline and at the end of treatment.

Results: Local treatment with CBD was significantly associated with lower pain scores, higher health assessment scores, and an increase in participants' total hours of sleep. Patients in the control group more frequently required additional analgesic therapy.

Conclusions: Topical CBD may be a valuable tool to treat pain related to digital ulcers in patients with SSc.

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Figures

Figure
Figure
DIGITAL ULCER BEFORE AND AFTER TOPICAL TREATMENT WITH CANNABIDIOL OIL A, Before treatment; B, after treatment.
See this image and copyright information in PMC

References

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