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Review
. 2023 Nov;52(11):2037-2043.
doi: 10.1007/s00256-022-04246-8. Epub 2022 Dec 20.

Crystal arthropathies and osteoarthritis-where is the link?

Mohamed Jarraya  1 , Frank Roemer  2   3 , C Kent Kwoh  4 , Ali Guermazi  2   5
Affiliations
Review

Crystal arthropathies and osteoarthritis-where is the link?

Mohamed Jarraya et al. Skeletal Radiol. 2023 Nov.

Abstract

Osteoarthritis (OA) is one of the leading causes of disability worldwide. As our understanding of OA progressively has moved from a purely mechanical "wear and tear" concept toward a complex multi-tissue condition in which inflammation plays a central role, the possible role of crystal-induced inflammation in OA incidence and progression may be relevant. In addition to gout, which affects 4% of the US population, basic calcium phosphate and calcium pyrophosphate deposition both may induce joint inflammation and may play a role in pain in OA. This narrative review article discusses the possible mechanisms underlying the associations between crystal-induced arthropathies and OA, and the important implications of these for clinical practice and future research.

Keywords: Calcium pyrophosphate; Gout; Monosodium urate; Osteoarthritis.

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