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. 2022 Dec 20;12(1):42.
doi: 10.1186/s12348-022-00319-w.

Ocular symptoms in COVID-19 infection: a survey study

Matthew McHarg  1   2 , Yujuan Wang  1 , Mehmet Yakin  1   3 , Alex Zeleny  1   4 , Sonny Caplash  5 , H Nida Sen  1 , Shilpa Kodati  6
Affiliations

Ocular symptoms in COVID-19 infection: a survey study

Matthew McHarg et al. J Ophthalmic Inflamm Infect. .

Abstract

Background: Coronavirus disease 2019 (COVID-19) systemic symptoms and sequelae have been studied extensively, but less is known about the characterization, duration, and long-term sequelae of ocular symptoms associated with COVID-19 infection. The purpose of this study was to analyze the frequency, spectrum, and duration of ocular symptoms in participants with COVID-19 infection treated in inpatient and outpatient settings.

Methods: A retrospective electronic survey was distributed to NIH employees and the public who reported testing positive for SARS-CoV-2. The anonymous survey collected information on demographics, past ocular history, systemic COVID-19 symptoms, and ocular symptoms.

Results: A total of 229 (21.9% male and 78.1% female, mean age 42.5 ± 13.9) survey responses were included. Ocular symptoms were reported by 165 participants with a mean of 2.31 ± 2.42 symptoms. The most commonly reported ocular symptoms were light sensitivity (31.0%), itchy eyes (24.9%), tearing (24.9%), eye redness (24.5%), and eye pain (24.5%). Participants with ocular symptoms had a higher number of systemic symptoms compared to participants without ocular symptoms (mean 9.17 ± 4.19 vs 6.22 ± 3.63; OR: 1.21; 95% CI: 1.11 - 1.32; p < 0.001). Ocular symptoms were more common in those who reported a past ocular history compared to those who did not (81.8% vs 67.1%; OR: 2.17; 95% CI: 1.08 - 4.37; p = 0.03). Additionally, the onset of ocular symptoms occurred most frequently at the same time as systemic symptoms (47.5%), and 21.8% reported symptoms lasting ≥ 14 days.

Conclusions: Ocular surface-related symptoms are the most frequent ocular manifestations, and systemic disease severity is associated with the presence of ocular symptoms. Additionally, our results show that ocular symptoms can persist post-COVID-19 infection. Further work is needed to better understand ocular symptoms in COVID-19 and long-term sequelae.

Keywords: COVID-19; Infection; Inflammation; Ocular surface; Survey study.

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Conflict of interest statement

The authors declare that they have no competing interests.

Update of

References

    1. Wu P, Duan F, Luo C, et al. Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. 2020;138(5):575–578. doi: 10.1001/jamaophthalmol.2020.1291. - DOI - PMC - PubMed
    1. Douglas KAA, Douglas VP, Moschos MM. Ocular Manifestations of COVID-19 (SARS-CoV-2): A Critical Review of Current Literature. In Vivo. 2020;34(3 Suppl):1619–1628. doi: 10.21873/invivo.11952. - DOI - PMC - PubMed
    1. Meduri A, Oliverio GW, Mancuso G, et al. Ocular surface manifestation of COVID-19 and tear film analysis. Sci Rep. 2020;10(1):20178. doi: 10.1038/s41598-020-77194-9. - DOI - PMC - PubMed
    1. Chen L, Deng C, Chen X, et al. Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China: a cross-sectional study. Acta Ophthalmol. 2020;98(8):e951–e959. doi: 10.1111/aos.14472. - DOI - PMC - PubMed
    1. Inomata T, Kitazawa K, Kuno T, et al. Clinical and Prodromal Ocular Symptoms in Coronavirus Disease: A Systematic Review and Meta-Analysis. Invest Ophthalmol Vis Sci. 2020;61(10):29. doi: 10.1167/iovs.61.10.29. - DOI - PMC - PubMed

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