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Comment
. 2022 Dec 20;15(765):eadg3025.
doi: 10.1126/scisignal.adg3025. Epub 2022 Dec 20.

Keeping brown fat brown

Amy E Baek  1
Affiliations
Comment

Keeping brown fat brown

Amy E Baek. Sci Signal. .

Abstract

The multilocular phenotype of brown adipose tissue is determined by an ER-lipid droplet anchoring protein.

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  • CLSTN3β enforces adipocyte multilocularity to facilitate lipid utilization.
    Qian K, Tol MJ, Wu J, Uchiyama LF, Xiao X, Cui L, Bedard AH, Weston TA, Rajendran PS, Vergnes L, Shimanaka Y, Yin Y, Jami-Alahmadi Y, Cohn W, Bajar BT, Lin CH, Jin B, DeNardo LA, Black DL, Whitelegge JP, Wohlschlegel JA, Reue K, Shivkumar K, Chen FJ, Young SG, Li P, Tontonoz P. Qian K, et al. Nature. 2023 Jan;613(7942):160-168. doi: 10.1038/s41586-022-05507-1. Epub 2022 Dec 7. Nature. 2023. PMID: 36477540 Free PMC article.

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