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Review
. 2023 Feb;19(8):e2204986.
doi: 10.1002/smll.202204986. Epub 2022 Dec 20.

Novel Nanoencapsulation Technology and its Potential Role in Bile Acid-Based Targeted Gene Delivery to the Inner Ear

Thomas Foster  1   2 , Michael Lewkowicz  1   2 , Christina Quintas  1 , Corina Mihaela Ionescu  1   2 , Melissa Jones  1   2 , Susbin Raj Wagle  1   2 , Bozica Kovacevic  1   2 , Elaine Y M Wong  2 , Armin Mooranian  1   2   3 , Hani Al-Salami  1   2   4
Affiliations
Review

Novel Nanoencapsulation Technology and its Potential Role in Bile Acid-Based Targeted Gene Delivery to the Inner Ear

Thomas Foster et al. Small. 2023 Feb.

Abstract

Hearing loss impacts a large proportion of the global population. Damage to the inner ear, in particular the sensitive hair cells, can impact individuals for the rest of their lives. There are very limited options for interventions after damage to these cells has occurred. Targeted gene delivery may provide an effective means to trigger appropriate differentiation of progenitor cells for effective replacement of these sensitive hair cells. There are several hurdles that need to be overcome to effectively deliver these genes. Nanoencapsulation technology has previously been used for the delivery of pharmaceuticals, proteins and nucleic acids, and may provide an effective means of delivering genes to trigger appropriate differentiation. This review investigates the background of hearing loss, current advancements and pitfalls of gene delivery, and how nanoencapsulation may be useful.

Keywords: bile acid; biomaterials; gene-delivery; hearing loss; nanotechnology.

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References

    1. P. W. Alberti, Occupational Exposure to Noise: Evaluation, Prevention, and Control, World Health Organisation: Geneva 2001, pp. 53-62.
    1. D. R. McPherson, Integr. Comp. Biol. 2018, 58, 282.
    1. Senate Community Affairs References Committee, Hear Us: Inquiry into Hearing Health in Australia, Parliament of Australia, Australia 2010.
    1. J. E. Lieu, M. Kenna, S. Anne, L. Davidson, JAMA, J. Am. Med. Assoc. 2020, 324, 2195.
    1. L. Shi, K. Liu, H. Wang, Y. Zhang, Z. Hong, M. Wang, X. Wang, X. Jiang, S. Yang, Acta Otolaryngol. 2015, 135, 1093.

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