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. 2022 Dec 20;12(1):21977.
doi: 10.1038/s41598-022-26229-4.

Risk factors associated with Retinopathy of Prematurity development and progression

Nieves de Las Rivas Ramírez  1   2 , Guillermo Luque Aranda  3 , Francisca Rius Díaz  4 , Francisco Javier Pérez Frías  5   6 , Tomás Sánchez Tamayo  5   6
Affiliations

Risk factors associated with Retinopathy of Prematurity development and progression

Nieves de Las Rivas Ramírez et al. Sci Rep. .

Abstract

Several studies propose that Retinopathy of Prematurity (ROP) is a multifactorial disorder implicating many prenatal and postnatal factors. The objective of our study was to determine the incidence and the risk factors that influenced ROP development and progression. We retrospectively compiled data of preterms with birth weight (BW) ≤ 1.500 g and/or gestational age (GA) < 32 weeks, or BW between 1.501 and 2.000 g and/or GA ≥ 32 weeks with oxygen supply > 72 h or unstable clinical course screened for ROP in Regional University Hospital of Málaga from 2015 to 2018. 202 infants (44.7%) developed ROP and 66 exhibited progression (32.7% of ROP infants). In the univariate analysis, many risk factors were associated with ROP. In the subsequent multivariate analysis, GA, oxygen therapy and weight at 28 days of life, mechanical ventilation duration, non-invasive ventilation, surfactant administration and late-onset sepsis were independently associated with the development. However, oxygen therapy duration, late-onset sepsis and weight at 28 days were associated with the progression. The ROP development and progression risk factors were different. Our results are important to facilitate screening, early diagnosis and ROP treatment while reducing unneeded examinations.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow diagram of the study. The chart on the left of the figure shows the exclusion reasons by year.
Figure 2
Figure 2
Tree algorithm for ROP development. GA gestational Age (weeks), MV mechanical Ventilation, NIV non-invasive ventilation. *p < 0.005.
Figure 3
Figure 3
Tree algorithm for ROP progression. *p < 0.005.
See this image and copyright information in PMC

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