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. 2023 Mar;23(3):135-136.
doi: 10.1038/s41577-022-00825-x.

Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

Yi Ju #  1   2 , Juan Manuel Carreño #  3   4 , Viviana Simon  3   4   5   6   7 , Kenneth Dawson  8 , Florian Krammer  9   10   11 , Stephen J Kent  12   13
Affiliations

Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

Yi Ju et al. Nat Rev Immunol. 2023 Mar.

Abstract

The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data show that PEG-specific antibodies can be induced or boosted by mRNA vaccination. Further research is needed to study the potential links between PEG-specific antibodies, vaccine reactogenicity and enhanced clearance of other PEG-containing medicines.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Induction of anti-PEG antibodies by mRNA vaccines.
Anti-polyethylene glycol (PEG) antibodies can be induced by mRNA–LNP vaccines, but the mechanisms involved and clinical impact of these antibodies are still unknown. The upper panel highlights potential factors that may influence PEG immunogenicity, whereas the lower panel summarises the potential clinical impact of anti-PEG antibodies induced by mRNA–LNP vaccines.
See this image and copyright information in PMC

References

    1. Chen BM, et al. Polyethylene glycol immunogenicity: theoretical, clinical, and practical aspects of anti-polyethylene glycol antibodies. ACS Nano. 2021;15:14022–14048. doi: 10.1021/acsnano.1c05922. - DOI - PubMed
    1. Ju Y, et al. Anti-PEG antibodies boosted in humans by SARS-CoV-2 lipid nanoparticle mRNA vaccine. ACS Nano. 2022;16:11769–11780. doi: 10.1021/acsnano.2c04543. - DOI - PubMed
    1. Carreño JM, et al. mRNA-1273 but not BNT162b2 induces antibodies against polyethylene glycol (PEG) contained in mRNA-based vaccine formulations. Vaccine. 2022;40:6114–6124. doi: 10.1016/j.vaccine.2022.08.024. - DOI - PMC - PubMed
    1. Guerrini G, et al. Monitoring anti-PEG antibodies level upon repeated lipid nanoparticle-based COVID-19 vaccine administration. Int. J. Mol. Sci. 2022;23:8838. doi: 10.3390/ijms23168838. - DOI - PMC - PubMed
    1. Kozma, G. T. et al. Role of anti-polyethylene glycol (PEG) antibodies in the allergic reactions and immunogenicity of PEG-containing COVID-19 vaccines. Preprint at medRxiv10.1101/2022.10.03.22280227 (2022). - PMC - PubMed